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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-5-19
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pubmed:abstractText |
The introduction of c-erbB-2 protein to clinical medicine as a prognostic indicator and tumor marker is desired. The authors determined the concentration of c-erbB-2 protein in 81 breast cancer tissues by enzyme immunoassay. The concentration of c-erbB-2 protein in breast cancer tissues showed a broad spectrum. A significant correlation was observed between tissue c-erbB-2 protein concentration and estrogen receptor status or immunohistochemical determination. In patients with distant metastases, there was a close association between c-erbB-2 protein concentration in the primary tumor and serum c-erbB-2 protein level. Cases with a high tumor concentration of c-erbB-2 protein (> 1000 U/mg total protein; 18.5% of cases) had a poor prognosis. From the above, we concluded the measurement of tissue c-erbB-2 protein by enzyme immunoassay to be clinically useful in breast cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0368-2811
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7908994-Breast,
pubmed-meshheading:7908994-Breast Neoplasms,
pubmed-meshheading:7908994-Follow-Up Studies,
pubmed-meshheading:7908994-Humans,
pubmed-meshheading:7908994-Immunoenzyme Techniques,
pubmed-meshheading:7908994-Neoplasm Metastasis,
pubmed-meshheading:7908994-Neoplasm Recurrence, Local,
pubmed-meshheading:7908994-Neoplasm Staging,
pubmed-meshheading:7908994-Prognosis,
pubmed-meshheading:7908994-Proto-Oncogene Proteins,
pubmed-meshheading:7908994-Receptor, Epidermal Growth Factor,
pubmed-meshheading:7908994-Receptor, erbB-2,
pubmed-meshheading:7908994-Receptors, Estrogen,
pubmed-meshheading:7908994-Survival Rate,
pubmed-meshheading:7908994-Tumor Markers, Biological
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pubmed:year |
1994
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pubmed:articleTitle |
Quantitative analysis of c-erbB-2 protein in breast cancer tissue by enzyme immunoassay.
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pubmed:affiliation |
Department of Surgery II, Nagoya University School of Medicine.
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pubmed:publicationType |
Journal Article
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