Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-8-8
pubmed:databankReference
pubmed:abstractText
From a newly determined cDNA sequence of the human ERK gene, a highly hydrophobic portion was identified upstream of the putative tyrosine kinase domain. This is the first evidence that the ERK protein possesses a receptor-like membrane-spanning structure. Fluorescence in situ hybridization analysis of R-banded metaphase chromosomes revealed that the ERK gene is located in chromosome region 1p36.1. This locus is near the frequent translocation breakpoint or deletion region of neuroblastoma and some other cancers. A comparative mapping study of the mouse and rat homologues indicated that each counterpart maps to the mouse chromosome 4D2.2-D3 and rat chromosome 5q36.13 regions, both of which have conserved linkage homology to human chromosome 1p.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0888-7543
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
26
pubmed:geneSymbol
ERK
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
382-4
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:7601466-Amino Acid Sequence, pubmed-meshheading:7601466-Animals, pubmed-meshheading:7601466-Base Sequence, pubmed-meshheading:7601466-Chickens, pubmed-meshheading:7601466-Chromosome Mapping, pubmed-meshheading:7601466-Chromosomes, Human, Pair 1, pubmed-meshheading:7601466-Genes, pubmed-meshheading:7601466-Humans, pubmed-meshheading:7601466-In Situ Hybridization, Fluorescence, pubmed-meshheading:7601466-Mice, pubmed-meshheading:7601466-Molecular Sequence Data, pubmed-meshheading:7601466-Nerve Tissue Proteins, pubmed-meshheading:7601466-Rats, pubmed-meshheading:7601466-Receptor, EphA8, pubmed-meshheading:7601466-Receptor, EphB2, pubmed-meshheading:7601466-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:7601466-Sequence Alignment, pubmed-meshheading:7601466-Sequence Homology, Amino Acid, pubmed-meshheading:7601466-Species Specificity
pubmed:year
1995
pubmed:articleTitle
Identification of the human ERK gene as a putative receptor tyrosine kinase and its chromosomal localization to 1p36.1: a comparative mapping of human, mouse, and rat chromosomes.
pubmed:affiliation
Division of Genetics, National Institute of Radiological Sciences, Chiba, Japan.
pubmed:publicationType
Journal Article, Comparative Study