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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1995-8-3
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pubmed:abstractText |
Macrophage colony-stimulating factor (M-CSF) is required for the growth and differentiation of mononuclear phagocytes. In the present studies using human monocytes, we show that M-CSF induces interaction of the Grb2 adaptor protein with the focal adhesion kinase pp125FAK. The results demonstrate that tyrosine-phosphorylated pp125FAK directly interacts with the SH2 domain of Grb2. The findings indicate that a pYENV site at Tyr-925 in pp125FAK is responsible for this interaction. We also demonstrate that the Grb2-FAK complex associates with the GTPase dynamin. Dynamin interacts with the SH3 domains of Grb2 and exhibits M-CSF-dependent tyrosine phosphorylation in association with pp125FAK. These findings suggest that M-CSF-induced signaling involves independent Grb2-mediated pathways, one leading to Ras activation and another involving pp125FAK and a GTPase implicated in receptor internalization.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-1314163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-1334462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-1379699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-1379745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-1382065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-1423600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-1429685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-1458538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-1465135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-15335710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-1652061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-1708916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-1840317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-1922035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-2110361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-2158859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-2172781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-2409450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-2482802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-2556641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-6309875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-7505391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-7509446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-7680959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-7681396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-7909355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-8013457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-8039498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-8051175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-8054685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-8101525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-8206897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-8262059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-8316835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-8357828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-8462097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-8479536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7597091-8493579
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Dynamins,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Protein-Tyrosine...,
http://linkedlifedata.com/resource/pubmed/chemical/GRB2 Adaptor Protein,
http://linkedlifedata.com/resource/pubmed/chemical/GRB2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Colony-Stimulating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/PTK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6132-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7597091-Humans,
pubmed-meshheading:7597091-Proteins,
pubmed-meshheading:7597091-Molecular Weight,
pubmed-meshheading:7597091-Monocytes,
pubmed-meshheading:7597091-Amino Acid Sequence,
pubmed-meshheading:7597091-Binding Sites,
pubmed-meshheading:7597091-Microtubules,
pubmed-meshheading:7597091-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:7597091-Molecular Sequence Data,
pubmed-meshheading:7597091-GTP Phosphohydrolases,
pubmed-meshheading:7597091-Receptor, Insulin,
pubmed-meshheading:7597091-Recombinant Proteins
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