Source:http://linkedlifedata.com/resource/umls/id/C0059239
CSP: nonEC; endogenous substrate for insulin receptor associated tyrosine kinase.,NCI: endogenous substrate for insulin receptor associated tyrosine kinase. (CSP98),NCI: Focal adhesion kinase (PTK2) lacks significant homology with other kinases and concentrates in focal adhesions between cells growing in extracellular matrix constituents. PTK2 contains phosphotyrosine in growing cells, or after treatment with cholecystokinin, bombesin, vasopressin, or endothelin, but little in detached cells. Activation of PTK2 may be important in signal transduction pathways triggered by neural peptides or by cell interactions with the extracellular matrix. PTK2 is a major substrate for pp60v-src. A CRK-associated tyrosine kinase substrate, p130-CAS, is a PTK2-interacting protein. This interaction requires the proline-rich region of PTK2 and the SH3 domain of p130-CAS. The interaction may also be a key element in integrin-mediated signal transduction and may represent a direct molecular link between the SRC and CRK oncoprote