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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5219
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pubmed:dateCreated |
1995-8-7
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pubmed:abstractText |
CD25 expression occurs early in thymocyte differentiation. The mechanism of induction of CD25 before T cell receptor rearrangement and the importance of this mechanism for T cell development are unknown. In a thymus reconstitution assay, tumor necrosis factor alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha), two cytokines produced within the thymic microenvironment, induced CD25 expression on early immature thymocytes. Either TNF-alpha or IL-1 alpha was necessary for further thymocyte maturation and CD4+CD8+ differentiation. In irradiated mice reconstituted with CD117+CD25+ thymocytes, commitment to the T cell lineage was marked by the loss of precursor multipotency.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
268
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1906-9
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pubmed:dateRevised |
2010-3-8
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pubmed:meshHeading |
pubmed-meshheading:7541554-Animals,
pubmed-meshheading:7541554-Cell Differentiation,
pubmed-meshheading:7541554-Cells, Cultured,
pubmed-meshheading:7541554-Hematopoietic Stem Cells,
pubmed-meshheading:7541554-Interleukin-1,
pubmed-meshheading:7541554-Interleukin-7,
pubmed-meshheading:7541554-Mice,
pubmed-meshheading:7541554-Mice, Inbred BALB C,
pubmed-meshheading:7541554-Mice, Inbred C57BL,
pubmed-meshheading:7541554-Mice, SCID,
pubmed-meshheading:7541554-Organ Culture Techniques,
pubmed-meshheading:7541554-Proto-Oncogene Proteins,
pubmed-meshheading:7541554-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:7541554-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:7541554-Receptors, Colony-Stimulating Factor,
pubmed-meshheading:7541554-Receptors, Interleukin-2,
pubmed-meshheading:7541554-Stromal Cells,
pubmed-meshheading:7541554-T-Lymphocyte Subsets,
pubmed-meshheading:7541554-T-Lymphocytes,
pubmed-meshheading:7541554-Thymus Gland,
pubmed-meshheading:7541554-Tumor Necrosis Factor-alpha
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pubmed:year |
1995
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pubmed:articleTitle |
Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation.
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pubmed:affiliation |
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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