Linked Life Data

7506554

Source:http://linkedlifedata.com/resource/pubmed/id/7506554

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1994-2-14
pubmed:abstractText
This study was designed to investigate the T cell costimulatory activity of ligands binding to different regions on the human CD4 molecule. We assayed the costimulatory properties of a panel of CD4 MAbs, intact HIV, and viral envelope glycoproteins in CD3-induced activation of resting T cell subpopulations. Our data using MAbs reveal epitope-specific variations in the functional activities of CD4 MAbs under specific conditions in which CD3 and CD4 molecules are co-cross-linked. We show that both naive and memory CD4+ T cell subsets are susceptible to CD4-mediated costimulation, which overcomes the functional differences between the two cell populations in responsiveness to CD3 MAbs. We show for the first time that, analogous to CD4 MAbs, preparations of HIV and viral envelope glycoprotein gp120 are also potent costimulators of T cell proliferation and IL-2 production. On the basis of these results we propose possible mechanisms for polyclonal cell activation in the course of HIV infection and suggest that viral inhibitory and costimulatory effects may together disrupt the normal balanced function of the immune system, leading to AIDS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0889-2229
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
945-55
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120.
pubmed:affiliation
Division of Hematologic Products, Food and Drug Administration, NIH, Bethesda, Maryland 20892.
pubmed:publicationType
Journal Article