Linked Life Data

7181200

Source:http://linkedlifedata.com/resource/pubmed/id/7181200

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1983-2-14
pubmed:abstractText
Rhesus macaques were inoculated subcutaneously with 40 plaque-forming units of yellow fever (YF) virus. To identify pathophysiologic mechanisms of YF, rectal temperatures and evidence of viremia were observed daily; physiologic and biochemical changes were studied on postinoculation day (PID) 5. Marked viremia was detected on PID 2 through 5, and fever was first observed on PID 4. On PID 5, blood and plasma volumes and circulatory K+ values increased, whereas RBC volume, PCV, and plasma cholesterol concentration decreased. Total lipids (mainly triglycerides) accumulated in the liver of inoculated macaques; alterations in hepatic content of water, electrolytes, and trace metals were also observed. Certain parts of the CNS, skeletal muscle, skin, heart, diaphragm, and renal cortex were affected, with changes noticed in water, electrolyte, trace metal, and lipid concentrations. These tissue changes indicated that cellular metabolism was altered and that the transport mechanisms of cell membranes of certain tissues were modified by YF virus or the disease process caused by the virus. Terminal hypoglycemia (57.6 +/- 12.1 mg/dl) was observed. The YF-induced intracellular dehydration of the medulla oblongata at the later stage of illness may depress the cardiovascular and respiratory centers, thus contributing to death of rhesus macaques infected with YF virus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9645
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2013-8
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Changes in body fluid compartments, tissue water and electrolyte distribution, and lipid concentrations in rhesus macaques with yellow fever.
pubmed:publicationType
Journal Article