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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4702
|
pubmed:dateCreated |
1985-6-27
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pubmed:abstractText |
Experiments were conducted to test the hypothesis that tumor-derived transforming growth factor-alpha (TGF-alpha) is responsible for the increased bone resorption and hypercalcemia seen in some malignant diseases. Homogeneous synthetic TGF-alpha prepared by the solid-phase synthesis method stimulated bone resorption directly in vitro in a concentration-dependent manner. Incubation times of 72 hours or more were required to stimulate resorption, which is similar to the time course of bone resorption by epidermal growth factor.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
24
|
pubmed:volume |
228
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1007-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3859011-Animals,
pubmed-meshheading:3859011-Bone Resorption,
pubmed-meshheading:3859011-Bone and Bones,
pubmed-meshheading:3859011-Dose-Response Relationship, Drug,
pubmed-meshheading:3859011-History, 20th Century,
pubmed-meshheading:3859011-Kinetics,
pubmed-meshheading:3859011-Molecular Weight,
pubmed-meshheading:3859011-Organ Culture Techniques,
pubmed-meshheading:3859011-Peptides,
pubmed-meshheading:3859011-Rats,
pubmed-meshheading:3859011-Transforming Growth Factors
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pubmed:year |
1985
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pubmed:articleTitle |
Stimulation of bone resorption in vitro by synthetic transforming growth factor-alpha.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Historical Article,
Research Support, Non-U.S. Gov't
|