| pubmed-article:21457712 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21457712 | lifeskim:mentions | umls-concept:C0249586 | lld:lifeskim |
| pubmed-article:21457712 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:21457712 | lifeskim:mentions | umls-concept:C0085262 | lld:lifeskim |
| pubmed-article:21457712 | lifeskim:mentions | umls-concept:C0085151 | lld:lifeskim |
| pubmed-article:21457712 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21457712 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:21457712 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:21457712 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:21457712 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:21457712 | pubmed:dateCreated | 2011-4-18 | lld:pubmed |
| pubmed-article:21457712 | pubmed:abstractText | The aim of the present study was to analyse the alterations of cyclin dependent kinase 5 (Cdk5) expression and phosphorylation in PC12 cells overexpressing amyloid precursor protein (APP). Our results demonstrated enhanced cell death and increased levels of mRNA for the Cdk5 gene in APP-transfected cells. Significantly decreased phosphorylation of Cdk5 at Tyr15 was observed in APPsw cells, which is responsible for a reduction in Cdk5 activity. Cdk5-dependent phosphorylation of glycogen synthase kinase-3? (Gsk-3?) at Ser9 was also decreased, which can lead to the increase of Gsk-3? activity and hyperphosphorylation of MAP tau. Our results demonstrate for the first time, a deregulation of Cdk5 phosphorylation in APP-transfected cells. | lld:pubmed |
| pubmed-article:21457712 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21457712 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457712 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21457712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21457712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457712 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21457712 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21457712 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21457712 | pubmed:issn | 1873-3468 | lld:pubmed |
| pubmed-article:21457712 | pubmed:author | pubmed-author:CzapskiGrzego... | lld:pubmed |
| pubmed-article:21457712 | pubmed:author | pubmed-author:StrosznajderJ... | lld:pubmed |
| pubmed-article:21457712 | pubmed:author | pubmed-author:SonginMartyna... | lld:pubmed |
| pubmed-article:21457712 | pubmed:author | pubmed-author:G?ssowskaMagd... | lld:pubmed |
| pubmed-article:21457712 | pubmed:author | pubmed-author:RadeckaUrszul... | lld:pubmed |
| pubmed-article:21457712 | pubmed:copyrightInfo | Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:21457712 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21457712 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:21457712 | pubmed:volume | 585 | lld:pubmed |
| pubmed-article:21457712 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21457712 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21457712 | pubmed:pagination | 1243-8 | lld:pubmed |
| pubmed-article:21457712 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:21457712 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21457712 | pubmed:articleTitle | Alterations of cyclin dependent kinase 5 expression and phosphorylation in amyloid precursor protein (APP)-transfected PC12 cells. | lld:pubmed |
| pubmed-article:21457712 | pubmed:affiliation | Department of Cellular Signaling, Mossakowski Medical Research Centre Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland. grzegorz@cmdik.pan.pl | lld:pubmed |
| pubmed-article:21457712 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21457712 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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