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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2011-4-18
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pubmed:abstractText |
The aim of the present study was to analyse the alterations of cyclin dependent kinase 5 (Cdk5) expression and phosphorylation in PC12 cells overexpressing amyloid precursor protein (APP). Our results demonstrated enhanced cell death and increased levels of mRNA for the Cdk5 gene in APP-transfected cells. Significantly decreased phosphorylation of Cdk5 at Tyr15 was observed in APPsw cells, which is responsible for a reduction in Cdk5 activity. Cdk5-dependent phosphorylation of glycogen synthase kinase-3? (Gsk-3?) at Ser9 was also decreased, which can lead to the increase of Gsk-3? activity and hyperphosphorylation of MAP tau. Our results demonstrate for the first time, a deregulation of Cdk5 phosphorylation in APP-transfected cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Protein Precursor,
http://linkedlifedata.com/resource/pubmed/chemical/Cdk5 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 5,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Purines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta,
http://linkedlifedata.com/resource/pubmed/chemical/roscovitine,
http://linkedlifedata.com/resource/pubmed/chemical/tau Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1873-3468
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
20
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pubmed:volume |
585
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1243-8
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:21457712-Amyloid beta-Protein Precursor,
pubmed-meshheading:21457712-Animals,
pubmed-meshheading:21457712-Blotting, Western,
pubmed-meshheading:21457712-Cell Survival,
pubmed-meshheading:21457712-Cyclin-Dependent Kinase 5,
pubmed-meshheading:21457712-Gene Expression,
pubmed-meshheading:21457712-Glycogen Synthase Kinase 3,
pubmed-meshheading:21457712-Humans,
pubmed-meshheading:21457712-PC12 Cells,
pubmed-meshheading:21457712-Phosphorylation,
pubmed-meshheading:21457712-Protein Kinase Inhibitors,
pubmed-meshheading:21457712-Purines,
pubmed-meshheading:21457712-RNA, Messenger,
pubmed-meshheading:21457712-Rats,
pubmed-meshheading:21457712-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21457712-Serine,
pubmed-meshheading:21457712-Transfection,
pubmed-meshheading:21457712-tau Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
Alterations of cyclin dependent kinase 5 expression and phosphorylation in amyloid precursor protein (APP)-transfected PC12 cells.
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pubmed:affiliation |
Department of Cellular Signaling, Mossakowski Medical Research Centre Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland. grzegorz@cmdik.pan.pl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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