|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0037083,
umls-concept:C0185117,
umls-concept:C0287990,
umls-concept:C0600388,
umls-concept:C0752312,
umls-concept:C0851285,
umls-concept:C0908063,
umls-concept:C0966897,
umls-concept:C1370600,
umls-concept:C1384665,
umls-concept:C1710082,
umls-concept:C2911684
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2010-11-1
|
|
pubmed:abstractText |
Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2. However, the role of these proteins in the regulation of hepcidin expression is unclear.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimicrobial Cationic Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/FURIN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Furin,
http://linkedlifedata.com/resource/pubmed/chemical/HFE protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hfe protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transferrin,
http://linkedlifedata.com/resource/pubmed/chemical/Smad Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TFR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transferrin,
http://linkedlifedata.com/resource/pubmed/chemical/Trfr2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/hepcidin
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1592-8721
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
95
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1832-40
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:20634490-Animals,
pubmed-meshheading:20634490-Antimicrobial Cationic Peptides,
pubmed-meshheading:20634490-Furin,
pubmed-meshheading:20634490-Gene Expression Regulation,
pubmed-meshheading:20634490-Hemochromatosis,
pubmed-meshheading:20634490-Hep G2 Cells,
pubmed-meshheading:20634490-Histocompatibility Antigens Class I,
pubmed-meshheading:20634490-Humans,
pubmed-meshheading:20634490-MAP Kinase Signaling System,
pubmed-meshheading:20634490-Membrane Proteins,
pubmed-meshheading:20634490-Mice,
pubmed-meshheading:20634490-Mice, Knockout,
pubmed-meshheading:20634490-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:20634490-Mutation,
pubmed-meshheading:20634490-Phosphorylation,
pubmed-meshheading:20634490-Receptors, Transferrin,
pubmed-meshheading:20634490-Smad Proteins,
pubmed-meshheading:20634490-Transferrin
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation.
|
|
pubmed:affiliation |
Dipartimento Materno Infantile e Tecnologie Biomediche, Facoltà di Medicina e Chirurgia, Università di Brescia, 25123 Brescia, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
