Source:http://linkedlifedata.com/resource/umls/id/C0287990
MSH: A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.,NCI: Paired basic amino acid cleaving enzyme. Product of the PACE gene. Required to convert transforming growth factor beta into its active form. Plays a significant role in tumor progression. Also called Furin.,NCI: Paired basic amino acid cleaving enzyme is an ubiquitous proprotein endoprotease that functions within secretory pathways and is localized in the trans Golgi network. PACE cleaves protein substrates at RX(K/R)R consensus motifs and plays a significant role in tumor progression. (from OMIM 136950 and NCI)