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skos:definition |
MSH: A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.,NCI: Paired basic amino acid cleaving enzyme. Product of the PACE gene. Required to convert transforming growth factor beta into its active form. Plays a significant role in tumor progression. Also called Furin.,NCI: Paired basic amino acid cleaving enzyme is an ubiquitous proprotein endoprotease that functions within secretory pathways and is localized in the trans Golgi network. PACE cleaves protein substrates at RX(K/R)R consensus motifs and plays a significant role in tumor progression. (from OMIM 136950 and NCI)
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