Source:http://linkedlifedata.com/resource/pubmed/id/20551150
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
2010-7-16
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pubmed:abstractText |
In our previous work, Ets-1 upregulates human epidermal growth factor receptor 2 (HER2) induced matrix metalloproteinase 1 (MMP-1) expression. Based on the above knowledge and result, we hypothesized that estrogen receptor (ER) and its signaling pathway may affect MMP-1 expression under the influence of HER2. In addition, we investigated how the HER2 pathway cross-talk with the ER signaling pathway in genomic and nongenomic action of ER using reverse transcription-PCR, Western blot analysis, and ELISA assay. The results showed that ER-alpha expression increased MMP-1 expression under the presence of HER2. These upregulatory effects were mediated mainly by mitogen-activated protein kinase pathway and were reversed by downregulation of HER2 and/or ER. Activator protein DNA binding activity was involved in the MMP-1 expression. In summary, our results showed that ER can upregulate MMP-1 expression under the influence of HER2 in MCF-7 cells. In addition, this upregulatory effect was found to be mediated by mitogen-activated protein kinase pathway. MMP-1 might be an assigned target in interaction between ER and HER2.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1557-3125
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pubmed:author |
pubmed-author:AhnJin SeokJS,
pubmed-author:HobeJJ,
pubmed-author:ImYoung-HyuckYH,
pubmed-author:JunHyun JungHJ,
pubmed-author:JungHae HyunHH,
pubmed-author:KimJeong HoonJH,
pubmed-author:KimJung AJA,
pubmed-author:KimSeung TaeST,
pubmed-author:KongJeehyunJ,
pubmed-author:LeeSoohyeonS,
pubmed-author:ParkYeon HeeYH,
pubmed-author:SunJong MuJM,
pubmed-author:WonYoung WoongYW
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1037-47
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pubmed:meshHeading |
pubmed-meshheading:20551150-Cell Line, Tumor,
pubmed-meshheading:20551150-Humans,
pubmed-meshheading:20551150-MAP Kinase Signaling System,
pubmed-meshheading:20551150-Matrix Metalloproteinase 1,
pubmed-meshheading:20551150-Mitogen-Activated Protein Kinases,
pubmed-meshheading:20551150-Receptor, Epidermal Growth Factor,
pubmed-meshheading:20551150-Receptors, Estrogen,
pubmed-meshheading:20551150-Signal Transduction,
pubmed-meshheading:20551150-Transfection,
pubmed-meshheading:20551150-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
Matrix metalloproteinase-1 expression can be upregulated through mitogen-activated protein kinase pathway under the influence of human epidermal growth factor receptor 2 synergized with estrogen receptor.
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pubmed:affiliation |
Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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