Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1991-6-21
|
| pubmed:abstractText |
In a randomized postoperative trial, adjuvant post-irradiation chemotherapy, consisting of nitrogen mustard, vincristine, procarbazine, and prednisone (MOPP), was tested versus radiation therapy alone for newly diagnosed medulloblastoma in patients between 1 and 21 years of age. Patients treated with irradiation plus MOPP had a statistically significant increase in overall survival rate at 5 years posttreatment compared to patients treated with radiation therapy alone (74% vs. 56%; p = 0.06, adjusted for race and gender). Although the overall study failed to show a statistically significant advantage for irradiation plus MOPP in event-free survival (p = 0.18), statistical significance was attained in children 5 years of age or older (p = 0.05). More severe hematological toxicities occurred in the group with irradiation plus MOPP; however, this hematotoxicity appeared to be tolerable and acceptable. These results suggest that patients may benefit from combined irradiation and chemotherapy following surgery for medulloblastoma.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-3085
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
74
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
905-9
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2033450-Adolescent,
pubmed-meshheading:2033450-Adult,
pubmed-meshheading:2033450-Age Factors,
pubmed-meshheading:2033450-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2033450-Cerebellar Neoplasms,
pubmed-meshheading:2033450-Child,
pubmed-meshheading:2033450-Child, Preschool,
pubmed-meshheading:2033450-Combined Modality Therapy,
pubmed-meshheading:2033450-Female,
pubmed-meshheading:2033450-Follow-Up Studies,
pubmed-meshheading:2033450-Humans,
pubmed-meshheading:2033450-Infant,
pubmed-meshheading:2033450-Male,
pubmed-meshheading:2033450-Mechlorethamine,
pubmed-meshheading:2033450-Medulloblastoma,
pubmed-meshheading:2033450-Prednisone,
pubmed-meshheading:2033450-Procarbazine,
pubmed-meshheading:2033450-Sex Factors,
pubmed-meshheading:2033450-Survival Rate,
pubmed-meshheading:2033450-Vincristine
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Nitrogen mustard, vincristine, procarbazine, and prednisone as adjuvant chemotherapy in the treatment of medulloblastoma. A Pediatric Oncology Group study.
|
| pubmed:affiliation |
Pediatric Oncology Group, St. Louis, Missouri.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial
|