Mechlorethamine

Source:http://linkedlifedata.com/resource/umls/id/C0025033

MSH: A vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage.,CSP: antineoplastic cytotoxic alkylating agent of the nitrogen mustard group.,CSP: group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen; formerly used as toxicants and vesicants, but now used therapeutically as antineoplastic agents; they are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.,NCI: A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lymphol

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