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rdf:type |
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lifeskim:mentions |
umls-concept:C0024432,
umls-concept:C0040649,
umls-concept:C0042071,
umls-concept:C0044602,
umls-concept:C0127400,
umls-concept:C0285761,
umls-concept:C0290068,
umls-concept:C0752313,
umls-concept:C0812281,
umls-concept:C1150481,
umls-concept:C1368105,
umls-concept:C1418755,
umls-concept:C1451005,
umls-concept:C1515877,
umls-concept:C1705325,
umls-concept:C1879547,
umls-concept:C2611812
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pubmed:issue |
1
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pubmed:dateCreated |
2009-9-11
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pubmed:abstractText |
We have recently shown that urokinase plasminogen activator (uPA) increases oxidative stress (OS), cholesterol biosynthesis, and paraoxonase 2 (PON2) expression in macrophages via binding to its receptor, the uPAR. Since PON2 is regulated by both OS and cholesterol content, we hypothesized that uPA elicits a cascade of signal transduction events shared by NADPH oxidase and cholesterol biosynthesis that culminates in PON2 gene expression. Here, we investigated the signalling pathway that leads to the expression of PON2 in macrophages in response to uPA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aryldialkylphosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/PON2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/SREBF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sterol Regulatory Element Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Plasminogen Activator,
http://linkedlifedata.com/resource/pubmed/chemical/Urokinase-Type Plasminogen Activator
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-54
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19497963-Aryldialkylphosphatase,
pubmed-meshheading:19497963-Cells, Cultured,
pubmed-meshheading:19497963-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:19497963-Gene Expression Regulation,
pubmed-meshheading:19497963-Humans,
pubmed-meshheading:19497963-Macrophages,
pubmed-meshheading:19497963-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:19497963-NADPH Oxidase,
pubmed-meshheading:19497963-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:19497963-Reactive Oxygen Species,
pubmed-meshheading:19497963-Receptor, Platelet-Derived Growth Factor beta,
pubmed-meshheading:19497963-Signal Transduction,
pubmed-meshheading:19497963-Sterol Regulatory Element Binding Protein 2,
pubmed-meshheading:19497963-Tissue Plasminogen Activator,
pubmed-meshheading:19497963-Transcription, Genetic,
pubmed-meshheading:19497963-Urokinase-Type Plasminogen Activator
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pubmed:year |
2009
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pubmed:articleTitle |
Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta.
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pubmed:affiliation |
The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel. fuhrman@tx.technion.ac.il
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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