Linked Life Data

18266230

Source:http://linkedlifedata.com/resource/pubmed/id/18266230

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pubmed-article:18266230pubmed:abstractTextPatients suffering from Crohn's disease (CD) show increased incidence of low bone mineral density. Investigating this complication is difficult because the exact etiology of CD remains elusive. Mice carrying a deletion in the tumor necrosis factor (TNF) AU-rich elements (ARE) are reported as a model for human CD and are characterized by elevated TNF-alpha levels and inflammations in the terminal ileum. To evaluate whether these mice have a Ca(2+) handling problem, this study analyzed the Ca(2+) homeostasis in heterozygous TNF(DeltaARE) mice (TNF(DeltaARE/+)) in comparison to wildtype littermates.lld:pubmed
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pubmed-article:18266230pubmed:articleTitleMurine TNF(DeltaARE) Crohn's disease model displays diminished expression of intestinal Ca2+ transporters.lld:pubmed
pubmed-article:18266230pubmed:affiliationDepartment of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands.lld:pubmed
pubmed-article:18266230pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18266230pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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