|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0010346,
umls-concept:C0017262,
umls-concept:C0021853,
umls-concept:C0185117,
umls-concept:C0205216,
umls-concept:C0591833,
umls-concept:C0596235,
umls-concept:C0596902,
umls-concept:C0684309,
umls-concept:C0812246,
umls-concept:C0870432,
umls-concept:C1456820,
umls-concept:C1555465,
umls-concept:C1705417,
umls-concept:C2911684
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|
pubmed:issue |
6
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|
pubmed:dateCreated |
2008-5-12
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|
pubmed:abstractText |
Patients suffering from Crohn's disease (CD) show increased incidence of low bone mineral density. Investigating this complication is difficult because the exact etiology of CD remains elusive. Mice carrying a deletion in the tumor necrosis factor (TNF) AU-rich elements (ARE) are reported as a model for human CD and are characterized by elevated TNF-alpha levels and inflammations in the terminal ileum. To evaluate whether these mice have a Ca(2+) handling problem, this study analyzed the Ca(2+) homeostasis in heterozygous TNF(DeltaARE) mice (TNF(DeltaARE/+)) in comparison to wildtype littermates.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1078-0998
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
14
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
803-11
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pubmed:meshHeading |
pubmed-meshheading:18266230-Animals,
pubmed-meshheading:18266230-Bone Resorption,
pubmed-meshheading:18266230-Calcitriol,
pubmed-meshheading:18266230-Calcium,
pubmed-meshheading:18266230-Crohn Disease,
pubmed-meshheading:18266230-Disease Models, Animal,
pubmed-meshheading:18266230-Female,
pubmed-meshheading:18266230-Homeostasis,
pubmed-meshheading:18266230-Intestines,
pubmed-meshheading:18266230-Mice,
pubmed-meshheading:18266230-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18266230-Tumor Necrosis Factor-alpha
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
Murine TNF(DeltaARE) Crohn's disease model displays diminished expression of intestinal Ca2+ transporters.
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|
pubmed:affiliation |
Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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