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rdf:type |
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lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0109317,
umls-concept:C0282549,
umls-concept:C0752312,
umls-concept:C1150579,
umls-concept:C1333340,
umls-concept:C1366882,
umls-concept:C1370600,
umls-concept:C1456820,
umls-concept:C1511938,
umls-concept:C1704259,
umls-concept:C1705767,
umls-concept:C1705791,
umls-concept:C1705987,
umls-concept:C1879547,
umls-concept:C2349975
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pubmed:issue |
2
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pubmed:dateCreated |
2008-3-4
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pubmed:abstractText |
The differentiation of promyelocytic leukemic cells into mature cells is the major strategy for drug-based treatment of leukemia. Higher efficient methods to differentiate promyelocytic leukemic cells have been developed using various differentiation inducers including interferon-alpha, interleukin-4, tumor necrosis factor-alpha (TNF-alpha), and dimethyl sulfoxide (DMSO) as a single agent or in combination with each other. Here, we show that a combination of TNF-alpha with DMSO shows a synergic effect on HL-60 cell differentiation through the activation of ERK pathway. TNF-alpha enhanced CD11b expression and percent of cell population in the G1 phase induced by DMSO, which are hallmarks for HL-60 cell differentiation. Inhibition of ERK pathway abolished the synergic effect of TNF-alpha in combination with DMSO on HL-60 differentiation, but the inhibition NF-kappaB pathway did not. These results suggest that TNF-alpha synergistically increases DMSO-induced differentiation of HL-60 cells through the activation of ERK/MAPK-signaling pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0925-5710
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pubmed:author |
pubmed-author:HanMyung-KwanMK,
pubmed-author:KimByeong-SooBS,
pubmed-author:KimJong-SukJS,
pubmed-author:LeeKyung-SunKS,
pubmed-author:LeeSeung JinSJ,
pubmed-author:LeeSung-HoSH,
pubmed-author:LeeYong-ChulYC,
pubmed-author:LeeYoung-RaeYR,
pubmed-author:NohEun-MiEM,
pubmed-author:ParkJinnyJ,
pubmed-author:SongEun-KyungEK,
pubmed-author:YimChang-YeolCY,
pubmed-author:YuHong-NuHN
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
189-94
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18256785-Cell Differentiation,
pubmed-meshheading:18256785-Dimethyl Sulfoxide,
pubmed-meshheading:18256785-Drug Synergism,
pubmed-meshheading:18256785-Drug Therapy, Combination,
pubmed-meshheading:18256785-Granulocyte Precursor Cells,
pubmed-meshheading:18256785-HL-60 Cells,
pubmed-meshheading:18256785-Humans,
pubmed-meshheading:18256785-MAP Kinase Signaling System,
pubmed-meshheading:18256785-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:18256785-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:18256785-Phosphorylation,
pubmed-meshheading:18256785-Tumor Necrosis Factor-alpha
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pubmed:year |
2008
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pubmed:articleTitle |
Tumor necrosis factor-alpha enhances DMSO-induced differentiation of HL-60 cells through the activation of ERK/MAPK pathway.
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pubmed:affiliation |
Department of Biochemistry, Institute of Medical Science, Chonbuk National University Medical School, Jeonju, Jeonbuk, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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