| pubmed-article:18160848 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18160848 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:18160848 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:18160848 | lifeskim:mentions | umls-concept:C0004112 | lld:lifeskim |
| pubmed-article:18160848 | lifeskim:mentions | umls-concept:C0038838 | lld:lifeskim |
| pubmed-article:18160848 | lifeskim:mentions | umls-concept:C0001515 | lld:lifeskim |
| pubmed-article:18160848 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:18160848 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18160848 | pubmed:dateCreated | 2007-12-27 | lld:pubmed |
| pubmed-article:18160848 | pubmed:abstractText | HIV-1 Tat is considered to be one of key players to facilitate monocyte entry into the CNS, which is characteristic feature of AIDS-related encephalitis and dementia. This study was performed to determine the regulatory function of superoxide dismutase (SOD) on the HIV-1 Tat-induced signaling pathways leading to NF-kappaB activation, expression of adhesion molecules, and monocyte adhesion in CRT-MG human astroglioma cells by using cell-permeable SOD. When cell-permeable SOD was added to the culture medium of CRT-MG cells, it rapidly entered the cells in dose- and time-dependent manners. Treatment of astrocytes with cell-permeable SOD led to decrease in Tat-induced ROS generation as well as NF-kappaB activation. Cell-permeable SOD inhibited the activation of MAP kinases including ERK, JNK and p38 by HIV-1 Tat. Treatment of CRT-MG cells with cell-permeable SOD significantly inhibited protein and mRNA levels of ICAM-1 and VCAM-1 up-regulated by HIV-1 Tat, as measured by Western blot analysis and RT-PCR. Furthermore, enhanced adhesiveness of monocyte to astrocyte by HIV-1 Tat was significantly abrogated by pretreatment with cell-permeable SOD fusion proteins. These data indicate that SOD has a regulatory function for HIV-1 Tat-induced NF-kappaB activation in astrocytes and suggest that cell-permeable SOD can be used as a feasible therapeutic agent for regulation of ROS-related neurological diseases. | lld:pubmed |
| pubmed-article:18160848 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18160848 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18160848 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18160848 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18160848 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18160848 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18160848 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18160848 | pubmed:issn | 1226-3613 | lld:pubmed |
| pubmed-article:18160848 | pubmed:author | pubmed-author:ChoiSoo... | lld:pubmed |
| pubmed-article:18160848 | pubmed:author | pubmed-author:ParkJinseuJ | lld:pubmed |
| pubmed-article:18160848 | pubmed:author | pubmed-author:JangSang HoSH | lld:pubmed |
| pubmed-article:18160848 | pubmed:author | pubmed-author:EumWon SikWS | lld:pubmed |
| pubmed-article:18160848 | pubmed:author | pubmed-author:KwonHyung-Joo... | lld:pubmed |
| pubmed-article:18160848 | pubmed:author | pubmed-author:JuSung MiSM | lld:pubmed |
| pubmed-article:18160848 | pubmed:author | pubmed-author:SongHa YongHY | lld:pubmed |
| pubmed-article:18160848 | pubmed:author | pubmed-author:LeeJi AeJA | lld:pubmed |
| pubmed-article:18160848 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18160848 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:18160848 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:18160848 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18160848 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18160848 | pubmed:pagination | 778-86 | lld:pubmed |
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| pubmed-article:18160848 | pubmed:meshHeading | pubmed-meshheading:18160848... | lld:pubmed |
| pubmed-article:18160848 | pubmed:meshHeading | pubmed-meshheading:18160848... | lld:pubmed |
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| pubmed-article:18160848 | pubmed:meshHeading | pubmed-meshheading:18160848... | lld:pubmed |
| pubmed-article:18160848 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:18160848 | pubmed:articleTitle | Suppression of HIV-1 Tat-induced monocyte adhesiveness by a cell-permeable superoxide dismutase in astrocytes. | lld:pubmed |
| pubmed-article:18160848 | pubmed:affiliation | Department of Biomedical Science, College of Natural Sciences, Hallym University, Chuncheon 200-702, Korea. | lld:pubmed |
| pubmed-article:18160848 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18160848 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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