Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-3383
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Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat,
HIV-1 Tat upregulates the expression of ICAM-1 in endothelial cells and astrocytes, an effect that is in part regulated by NF-kappa B and may be associated with AIDS-related Kaposi's sarcoma,
HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 is blocked by NADPH oxidase inhibitor,
Inhibition of human telomerase reverse transcriptase (hTERT) results in the upregulation of HIV-1 Tat-induced overexpression of intercellular adhesion molecule-1 (ICAM1) via the nuclear factor-kappaB-regulated mechanism,
Treatment of monocytes with HIV-1 Tat increases their adhesion to endothelial monolayers, an effect that is inhibited by anti-ICAM-1 Abs, suggesting an interaction between Tat and ICAM-1
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interacts with,
upregulates
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