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rdf:type |
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lifeskim:mentions |
umls-concept:C0003018,
umls-concept:C0017262,
umls-concept:C0030190,
umls-concept:C0068355,
umls-concept:C0079904,
umls-concept:C0185117,
umls-concept:C0206136,
umls-concept:C0332325,
umls-concept:C0441655,
umls-concept:C1280500,
umls-concept:C1337092,
umls-concept:C1522558,
umls-concept:C1565860,
umls-concept:C1705079,
umls-concept:C1705323,
umls-concept:C1882714,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2007-11-16
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pubmed:abstractText |
Chronic consumption of a high-salt diet causes hypertension (HTN) and renal injury in Dahl salt-sensitive (SSR) but not salt-resistant rats (SRR). These events are, in part, mediated by oxidative stress and inflammation in the kidney and vascular tissues. Activation of the angiotensin II type 1 (AT(1)) receptor plays an important role in the pathogenesis of oxidative stress and inflammation in many hypertensive disorders. However, the systemic renin-angiotensin system (RAS) is typically suppressed in salt-sensitive HTN. This study was designed to test the hypothesis that differential response to a high-salt diet in SSR versus SRR may be related to upregulation of tissue RAS and pathways involved in inflammation and reactive oxygen species (ROS) production.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Ccl2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/I kappa B beta protein,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Plasminogen Activator Inhibitor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Ptgs2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Renin,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride, Dietary
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pubmed:status |
MEDLINE
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pubmed:issn |
1421-9670
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2007 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
158-67
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pubmed:meshHeading |
pubmed-meshheading:17951998-Angiotensin II,
pubmed-meshheading:17951998-Animals,
pubmed-meshheading:17951998-Antioxidants,
pubmed-meshheading:17951998-Chemokine CCL2,
pubmed-meshheading:17951998-Cyclooxygenase 2,
pubmed-meshheading:17951998-Hypertension, Renal,
pubmed-meshheading:17951998-I-kappa B Proteins,
pubmed-meshheading:17951998-Kidney,
pubmed-meshheading:17951998-Macrophages,
pubmed-meshheading:17951998-Male,
pubmed-meshheading:17951998-NADPH Oxidase,
pubmed-meshheading:17951998-NF-kappa B,
pubmed-meshheading:17951998-Phosphorylation,
pubmed-meshheading:17951998-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:17951998-Rats,
pubmed-meshheading:17951998-Rats, Inbred Dahl,
pubmed-meshheading:17951998-Receptor, Angiotensin, Type 1,
pubmed-meshheading:17951998-Renin,
pubmed-meshheading:17951998-Renin-Angiotensin System,
pubmed-meshheading:17951998-Sodium Chloride, Dietary,
pubmed-meshheading:17951998-T-Lymphocytes
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pubmed:year |
2008
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pubmed:articleTitle |
Effects of dietary salt on intrarenal angiotensin system, NAD(P)H oxidase, COX-2, MCP-1 and PAI-1 expressions and NF-kappaB activity in salt-sensitive and -resistant rat kidneys.
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pubmed:affiliation |
Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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