rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
7
|
pubmed:dateCreated |
2007-7-6
|
pubmed:abstractText |
Interleukin-17 (IL-17) is a pro-inflammatory cytokine produced from CD4+ T cells and is associated with neutrophilia in infection, ischemia-reperfusion injury, and possibly acute and chronic rejection (bronchiolitis obliterans syndrome, or BOS) after lung transplantation (LTx). Everolimus (ERL) decreases acute rejection, possibly via decreasing airway CD4+ cells and neutrophils. This prospective study aims to assess: (1) the possible role of IL-17 as a link between LTx clinical outcomes (such as infection, acute rejection and BOS) and airway immunopathologic measures from endobronchial biopsy (EBB) and bronchoalveolar lavage (BAL); and (2) any differences in IL-17 production between ERL and azathioprine (AZA)-based immunosuppression.
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
1557-3117
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
26
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
669-74
|
pubmed:meshHeading |
pubmed-meshheading:17613395-Azathioprine,
pubmed-meshheading:17613395-Biopsy,
pubmed-meshheading:17613395-Bronchoalveolar Lavage,
pubmed-meshheading:17613395-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17613395-Double-Blind Method,
pubmed-meshheading:17613395-Female,
pubmed-meshheading:17613395-Gene Expression Regulation,
pubmed-meshheading:17613395-Graft Rejection,
pubmed-meshheading:17613395-Humans,
pubmed-meshheading:17613395-Immunosuppressive Agents,
pubmed-meshheading:17613395-Interleukin-17,
pubmed-meshheading:17613395-Lung,
pubmed-meshheading:17613395-Lung Transplantation,
pubmed-meshheading:17613395-Male,
pubmed-meshheading:17613395-Middle Aged,
pubmed-meshheading:17613395-Pneumonia,
pubmed-meshheading:17613395-Prospective Studies,
pubmed-meshheading:17613395-Sirolimus
|
pubmed:year |
2007
|
pubmed:articleTitle |
Interleukin-17 and airway inflammation: a longitudinal airway biopsy study after lung transplantation.
|
pubmed:affiliation |
Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Monash University, Melbourne, Victoria, Australia. g.snell@alfred.org.au
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|