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rdf:type |
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lifeskim:mentions |
umls-concept:C0016030,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0023688,
umls-concept:C0027430,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0282552,
umls-concept:C0752312,
umls-concept:C1456820,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2007-4-11
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pubmed:abstractText |
Recruitment of macrophages is crucial to the pathogenesis of the nasal polyp (NP) because this disease is believed to be inflammation related. Information regarding the expression of C-C chemokine ligand 2 (CCL2), an essential modulator of monocyte chemotaxis in nasal polyp fibroblasts (NPFs), remains unavailable. In this study, the effects of tumor necrosis factor (TNF)-a on CCL2 expression in NPFs and the signaling pathway involved were investigated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCL2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins B-raf,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:issn |
1050-6586
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17424890-Blotting, Northern,
pubmed-meshheading:17424890-Blotting, Western,
pubmed-meshheading:17424890-Cells, Cultured,
pubmed-meshheading:17424890-Chemokine CCL2,
pubmed-meshheading:17424890-Fibroblasts,
pubmed-meshheading:17424890-Gene Expression,
pubmed-meshheading:17424890-Genes, fos,
pubmed-meshheading:17424890-Genes, jun,
pubmed-meshheading:17424890-Humans,
pubmed-meshheading:17424890-MAP Kinase Kinase Kinase 1,
pubmed-meshheading:17424890-MAP Kinase Kinase Kinase 2,
pubmed-meshheading:17424890-MAP Kinase Signaling System,
pubmed-meshheading:17424890-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:17424890-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:17424890-Mitogen-Activated Protein Kinases,
pubmed-meshheading:17424890-Nasal Polyps,
pubmed-meshheading:17424890-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:17424890-Signal Transduction,
pubmed-meshheading:17424890-Transcription Factor AP-1,
pubmed-meshheading:17424890-Tumor Necrosis Factor-alpha,
pubmed-meshheading:17424890-p38 Mitogen-Activated Protein Kinases
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pubmed:articleTitle |
Tumor necrosis factor-alpha stimulates the expression of C-C chemokine ligand 2 gene in fibroblasts from the human nasal polyp through the pathways of mitogen-activated protein kinase.
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pubmed:affiliation |
Department of Dentistry, National Taiwan University Hospital, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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