Source:http://linkedlifedata.com/resource/pubmed/id/17360775
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2007-3-23
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| pubmed:abstractText |
Photoreceptor cell axons (R axons) innervate optic ganglia in the Drosophila brain through the tubular optic stalk. This structure consists of surface glia (SG) and forms independently of R axon projection. In a screen for genes involved in optic stalk formation, we identified Fak56D encoding a Drosophila homolog of mammalian focal adhesion kinase (FAK). FAK is a main component of the focal adhesion signaling that regulates various cellular events, including cell migration and morphology. We show that Fak56D mutation causes severe disruption of the optic stalk structure. These phenotypes were completely rescued by Fak56D transgene expression in the SG cells but not in photoreceptor cells. Moreover, Fak56D genetically interacts with myospheroid, which encodes an integrin beta subunit. In addition, we found that CdGAPr is also required for optic stalk formation and genetically interacts with Fak56D. CdGAPr encodes a GTPase-activating domain that is homologous to that of mammalian CdGAP, which functions in focal adhesion signaling. Hence the optic stalk is a simple monolayered structure that can serve as an ideal system for studying glial cell morphogenesis and the developmental role(s) of focal adhesion signaling.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CdGAPr protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fak56D protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin beta Chains
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0950-1991
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
134
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1539-48
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:17360775-Animals,
pubmed-meshheading:17360775-Axons,
pubmed-meshheading:17360775-Cell Movement,
pubmed-meshheading:17360775-Drosophila,
pubmed-meshheading:17360775-Drosophila Proteins,
pubmed-meshheading:17360775-Focal Adhesion Kinase 1,
pubmed-meshheading:17360775-Focal Adhesions,
pubmed-meshheading:17360775-GTPase-Activating Proteins,
pubmed-meshheading:17360775-Integrin beta Chains,
pubmed-meshheading:17360775-Larva,
pubmed-meshheading:17360775-Male,
pubmed-meshheading:17360775-Morphogenesis,
pubmed-meshheading:17360775-Mutation,
pubmed-meshheading:17360775-Neuroglia,
pubmed-meshheading:17360775-Photoreceptor Cells, Invertebrate,
pubmed-meshheading:17360775-Protein Structure, Tertiary,
pubmed-meshheading:17360775-Retina,
pubmed-meshheading:17360775-Signal Transduction
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| pubmed:year |
2007
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| pubmed:articleTitle |
Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk.
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| pubmed:affiliation |
Laboratory of Morphogenesis, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo 113-0032, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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