pubmed-article:16920714 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C1370600 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C1366765 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:16920714 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:16920714 | pubmed:issue | 42 | lld:pubmed |
pubmed-article:16920714 | pubmed:dateCreated | 2006-10-16 | lld:pubmed |
pubmed-article:16920714 | pubmed:abstractText | Human immunodeficiency virus (HIV)-Tat plays an important role in virus replication and in various aspects of host immune responses, including dysregulation of cytokine production. IL-10, an anti-inflammatory cytokine, is up-regulated during the course of HIV infection representing an important pathway by which HIV may induce immunodeficiency. Here we show that extracellular as well as intracellular Tat induced IL-10 expression in normal human monocytes and promonocytic THP-1 cells. The signaling pathways involved in the regulation of IL-10 production by endogenous Tat remain unknown. To understand the molecular mechanism underlying intracellular Tat-induced IL-10 transcription, we employed a retroviral expression system to investigate the role of MAPKs and the transcription factor(s) involved. Our results suggest that an inhibitor specific for the ERK1/2, PD98059, selectively blocked intracellular Tat-induced IL-10 expression in THP-1 cells. Furthermore, intracellular Tat activated the CREB-1 transcription factor through Ser(133) phosphorylation that was regulated by ERK MAPK as determined by IL-10 promoter analysis and gel shift assays. Overall, our results suggest that intracellular HIV-Tat induces IL-10 transcription by ERK MAPK-dependent CREB-1 transcription factor activation through Ser(133) phosphorylation. | lld:pubmed |
pubmed-article:16920714 | pubmed:language | eng | lld:pubmed |
pubmed-article:16920714 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16920714 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:16920714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:16920714 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:16920714 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:16920714 | pubmed:month | Oct | lld:pubmed |
pubmed-article:16920714 | pubmed:issn | 0021-9258 | lld:pubmed |
pubmed-article:16920714 | pubmed:author | pubmed-author:YewDD | lld:pubmed |
pubmed-article:16920714 | pubmed:author | pubmed-author:KumarAshokA | lld:pubmed |
pubmed-article:16920714 | pubmed:author | pubmed-author:GeeKatrinaK | lld:pubmed |
pubmed-article:16920714 | pubmed:author | pubmed-author:AngelJonathan... | lld:pubmed |
pubmed-article:16920714 | pubmed:author | pubmed-author:ParatoKarlK | lld:pubmed |
pubmed-article:16920714 | pubmed:author | pubmed-author:MishraSasmita... | lld:pubmed |
pubmed-article:16920714 | pubmed:author | pubmed-author:GajanayakaNir... | lld:pubmed |
pubmed-article:16920714 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:16920714 | pubmed:day | 20 | lld:pubmed |
pubmed-article:16920714 | pubmed:volume | 281 | lld:pubmed |
pubmed-article:16920714 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:16920714 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:16920714 | pubmed:pagination | 31647-58 | lld:pubmed |
pubmed-article:16920714 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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pubmed-article:16920714 | pubmed:meshHeading | pubmed-meshheading:16920714... | lld:pubmed |
pubmed-article:16920714 | pubmed:year | 2006 | lld:pubmed |
pubmed-article:16920714 | pubmed:articleTitle | Intracellular HIV-Tat expression induces IL-10 synthesis by the CREB-1 transcription factor through Ser133 phosphorylation and its regulation by the ERK1/2 MAPK in human monocytic cells. | lld:pubmed |
pubmed-article:16920714 | pubmed:affiliation | Department of Pathology, Division of Virology, Research Institute, Children's Hospital of Eastern Ontario, Ottawa K1H 8L1, Canada. | lld:pubmed |
pubmed-article:16920714 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:16920714 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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