Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-1385
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| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
Extracellular HIV-1 Tat protein induces the rapid Ser-133 phosphorylation and activation of CREB transcription factor in lymphoid cells through a signal cascade involving the MAPK pathway,
HIV-1 Tat increases both CREB phosphorylation and DNA binding by 7- to 10-fold within 2 hours after stimulation in hematopoietic progenitor cells,
HIV-1 Tat induces upregulation of HDAC2 expression and downregulation of CREB and CaMKIIa expression in human neuroblastoma SK-N-MC cells,
HIV-1 Tat protein downregulates the Ser-133 phosphorylation, activation, and expression of CREB transcription factor in PC12 neuronal cells through sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases,
HIV-1 Tat upregulates IL-10 synthesis by ERK MAPK-dependent CREB-1 transcription factor activation through Ser(133) phosphorylation,
Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors,
The CKLF-like MARVEL transmembrane domain-containing family 2 (CMTM2) blocks HIV-1 Tat-induced AP-1 and CREB activation, which leads to suppress HIV-1 provirus transcription,
The function and activity of CREB is required for both Tat-induced Rho signaling and nuclear targeting of ZO-1
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| entrezgene:keyphrase |
downregulates,
induces phosphorylation of,
regulated by,
requires,
activates
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