16243232

Source:http://linkedlifedata.com/resource/pubmed/id/16243232

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017262, umls-concept:C0021760, umls-concept:C0025543, umls-concept:C0029418, umls-concept:C0069535, umls-concept:C0081487, umls-concept:C0185117, umls-concept:C0225369, umls-concept:C0262950, umls-concept:C0334135, umls-concept:C1176299, umls-concept:C1280500, umls-concept:C2911684
pubmed:issue	11
pubmed:dateCreated	2005-10-24
pubmed:abstractText	To determine the effects of osteoarthritic (OA) subchondral osteoblasts on the metabolism of human OA chondrocytes in alginate beads.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9305697
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Aggrecans, http://linkedlifedata.com/resource/pubmed/chemical/Collagenases, http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6, http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type, http://linkedlifedata.com/resource/pubmed/chemical/MMP13 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 13, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 3, http://linkedlifedata.com/resource/pubmed/chemical/Metalloproteases, http://linkedlifedata.com/resource/pubmed/chemical/OSM protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Oncostatin M, http://linkedlifedata.com/resource/pubmed/chemical/Peptides, http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	1063-4584
pubmed:author	pubmed-author:DebergM AMA, pubmed-author:HenrotinY EYE, pubmed-author:MsikaPP, pubmed-author:PiccardiNN, pubmed-author:ReginsterJ-Y LJY, pubmed-author:SanchezCC
pubmed:issnType	Print
pubmed:volume	13
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	979-87
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:16243232-Aged, pubmed-meshheading:16243232-Aggrecans, pubmed-meshheading:16243232-Cadaver, pubmed-meshheading:16243232-Chondrocytes, pubmed-meshheading:16243232-Coculture Techniques, pubmed-meshheading:16243232-Collagenases, pubmed-meshheading:16243232-Down-Regulation, pubmed-meshheading:16243232-Extracellular Matrix Proteins, pubmed-meshheading:16243232-Femur, pubmed-meshheading:16243232-Gene Expression, pubmed-meshheading:16243232-Growth Inhibitors, pubmed-meshheading:16243232-Humans, pubmed-meshheading:16243232-Interleukin-1, pubmed-meshheading:16243232-Interleukin-6, pubmed-meshheading:16243232-Lectins, C-Type, pubmed-meshheading:16243232-Male, pubmed-meshheading:16243232-Matrix Metalloproteinase 13, pubmed-meshheading:16243232-Matrix Metalloproteinase 3, pubmed-meshheading:16243232-Metalloproteases, pubmed-meshheading:16243232-Middle Aged, pubmed-meshheading:16243232-Oncostatin M, pubmed-meshheading:16243232-Osteoarthritis, Knee, pubmed-meshheading:16243232-Osteoblasts, pubmed-meshheading:16243232-Peptides, pubmed-meshheading:16243232-Phenotype, pubmed-meshheading:16243232-Proteoglycans, pubmed-meshheading:16243232-Sclerosis, pubmed-meshheading:16243232-Tibia, pubmed-meshheading:16243232-Up-Regulation
pubmed:year	2005
pubmed:articleTitle	Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts.
pubmed:affiliation	Bone and Cartilage Metabolism Research Unit, Institute of Pathology B23, University Hospital, Sart-Tilman, 4000 Liège, Belgium.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't