| pubmed-article:15972689 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15972689 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
| pubmed-article:15972689 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:15972689 | lifeskim:mentions | umls-concept:C0063695 | lld:lifeskim |
| pubmed-article:15972689 | lifeskim:mentions | umls-concept:C0078056 | lld:lifeskim |
| pubmed-article:15972689 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:15972689 | lifeskim:mentions | umls-concept:C0666364 | lld:lifeskim |
| pubmed-article:15972689 | lifeskim:mentions | umls-concept:C1367028 | lld:lifeskim |
| pubmed-article:15972689 | lifeskim:mentions | umls-concept:C1523116 | lld:lifeskim |
| pubmed-article:15972689 | lifeskim:mentions | umls-concept:C0001515 | lld:lifeskim |
| pubmed-article:15972689 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15972689 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:15972689 | lifeskim:mentions | umls-concept:C1449799 | lld:lifeskim |
| pubmed-article:15972689 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15972689 | pubmed:dateCreated | 2005-6-23 | lld:pubmed |
| pubmed-article:15972689 | pubmed:abstractText | Inflammation is a basic pathological mechanism leading to a variety of vascular diseases. The inflammatory reaction involves complex interactions between both circulating and resident leukocytes and the vascular endothelium. In this study, we report evidence for a novel action of TNF-related activation-induced cytokine (TRANCE) as an inflammatory mediator and its underlying signaling mechanism in the vascular wall. TRANCE significantly increased endothelial-leukocyte cell interactions, and this effect was associated with increased expression of the cell adhesion molecules, ICAM-1 and VCAM-1, on the endothelial cells. RT-PCR analysis and promoter assays revealed that expression of these cell adhesion molecules was transcriptionally regulated mainly by activation of the inflammatory transcription factor, NF-kappaB. TRANCE induced IkappaB-alpha phosphorylation and NF-kappaB activation via a cascade of reactions involving the TNFR-associated factors, phospholipase C, PI3K, and protein kinase C (PKC-alpha and PKC-zeta). It also led to the production of reactive oxygen species via PKC- and PI3K-dependent activation of NADPH oxidase in the endothelial cells, and antioxidants suppressed the responses to TRANCE. These results demonstrate that TRANCE has an inflammatory action and may play a role in the pathogenesis of inflammation-related diseases. | lld:pubmed |
| pubmed-article:15972689 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15972689 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15972689 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15972689 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15972689 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15972689 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15972689 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15972689 | pubmed:author | pubmed-author:KongYoung-Yun... | lld:pubmed |
| pubmed-article:15972689 | pubmed:author | pubmed-author:HwangIn KooIK | lld:pubmed |
| pubmed-article:15972689 | pubmed:author | pubmed-author:WonMoo HoMH | lld:pubmed |
| pubmed-article:15972689 | pubmed:author | pubmed-author:KwonYoung-Gue... | lld:pubmed |
| pubmed-article:15972689 | pubmed:author | pubmed-author:KimSung WanSW | lld:pubmed |
| pubmed-article:15972689 | pubmed:author | pubmed-author:RhoJaerangJ | lld:pubmed |
| pubmed-article:15972689 | pubmed:author | pubmed-author:KimYoung-Myeo... | lld:pubmed |
| pubmed-article:15972689 | pubmed:author | pubmed-author:MinJeong-KiJK | lld:pubmed |
| pubmed-article:15972689 | pubmed:author | pubmed-author:KwonMin-ChulM... | lld:pubmed |
| pubmed-article:15972689 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15972689 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15972689 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:15972689 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15972689 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15972689 | pubmed:pagination | 531-40 | lld:pubmed |
| pubmed-article:15972689 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15972689 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15972689 | pubmed:articleTitle | TNF-related activation-induced cytokine enhances leukocyte adhesiveness: induction of ICAM-1 and VCAM-1 via TNF receptor-associated factor and protein kinase C-dependent NF-kappaB activation in endothelial cells. | lld:pubmed |
| pubmed-article:15972689 | pubmed:affiliation | Department of Biochemistry, College of Sciences, Yonsei University, Seoul, Republic of Korea. | lld:pubmed |
| pubmed-article:15972689 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15972689 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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