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rdf:type |
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lifeskim:mentions |
umls-concept:C0001515,
umls-concept:C0023516,
umls-concept:C0033640,
umls-concept:C0063695,
umls-concept:C0078056,
umls-concept:C0205263,
umls-concept:C0225336,
umls-concept:C0666364,
umls-concept:C1367028,
umls-concept:C1449799,
umls-concept:C1523116,
umls-concept:C2349975
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pubmed:issue |
1
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pubmed:dateCreated |
2005-6-23
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pubmed:abstractText |
Inflammation is a basic pathological mechanism leading to a variety of vascular diseases. The inflammatory reaction involves complex interactions between both circulating and resident leukocytes and the vascular endothelium. In this study, we report evidence for a novel action of TNF-related activation-induced cytokine (TRANCE) as an inflammatory mediator and its underlying signaling mechanism in the vascular wall. TRANCE significantly increased endothelial-leukocyte cell interactions, and this effect was associated with increased expression of the cell adhesion molecules, ICAM-1 and VCAM-1, on the endothelial cells. RT-PCR analysis and promoter assays revealed that expression of these cell adhesion molecules was transcriptionally regulated mainly by activation of the inflammatory transcription factor, NF-kappaB. TRANCE induced IkappaB-alpha phosphorylation and NF-kappaB activation via a cascade of reactions involving the TNFR-associated factors, phospholipase C, PI3K, and protein kinase C (PKC-alpha and PKC-zeta). It also led to the production of reactive oxygen species via PKC- and PI3K-dependent activation of NADPH oxidase in the endothelial cells, and antioxidants suppressed the responses to TRANCE. These results demonstrate that TRANCE has an inflammatory action and may play a role in the pathogenesis of inflammation-related diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/RANK Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activator of Nuclear...,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TNF Receptor-Associated Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/TNF Receptor-Associated Factor 6,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF11A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
531-40
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15972689-Base Sequence,
pubmed-meshheading:15972689-Carrier Proteins,
pubmed-meshheading:15972689-Cell Adhesion,
pubmed-meshheading:15972689-Cells, Cultured,
pubmed-meshheading:15972689-DNA,
pubmed-meshheading:15972689-Endothelium, Vascular,
pubmed-meshheading:15972689-Humans,
pubmed-meshheading:15972689-I-kappa B Proteins,
pubmed-meshheading:15972689-Intercellular Adhesion Molecule-1,
pubmed-meshheading:15972689-Leukocytes,
pubmed-meshheading:15972689-Membrane Glycoproteins,
pubmed-meshheading:15972689-Models, Biological,
pubmed-meshheading:15972689-NF-kappa B,
pubmed-meshheading:15972689-Phosphorylation,
pubmed-meshheading:15972689-Protein Kinase C,
pubmed-meshheading:15972689-RANK Ligand,
pubmed-meshheading:15972689-RNA, Messenger,
pubmed-meshheading:15972689-Reactive Oxygen Species,
pubmed-meshheading:15972689-Receptor Activator of Nuclear Factor-kappa B,
pubmed-meshheading:15972689-Recombinant Proteins,
pubmed-meshheading:15972689-Signal Transduction,
pubmed-meshheading:15972689-TNF Receptor-Associated Factor 2,
pubmed-meshheading:15972689-TNF Receptor-Associated Factor 6,
pubmed-meshheading:15972689-Transfection,
pubmed-meshheading:15972689-U937 Cells,
pubmed-meshheading:15972689-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2005
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pubmed:articleTitle |
TNF-related activation-induced cytokine enhances leukocyte adhesiveness: induction of ICAM-1 and VCAM-1 via TNF receptor-associated factor and protein kinase C-dependent NF-kappaB activation in endothelial cells.
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pubmed:affiliation |
Department of Biochemistry, College of Sciences, Yonsei University, Seoul, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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