|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2004-12-20
|
|
pubmed:abstractText |
In a case-control study using a clinically well-defined group of 41 multiple system atrophy (MSA) patients and 93 control subjects, the interleukin (IL)-8 (-251) TT genotype was associated with an approximately fourfold increased risk for MSA and, furthermore, this risk increased elevenfold with the simultaneous presence of the intercellular adhesion molecule-1 (ICAM-1: E469K) KK genotype, suggesting a gene-gene interaction. These data support a role for inflammation-related genes in risk for MSA.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0022-510X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
228
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
11-3
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15607204-Adult,
pubmed-meshheading:15607204-Aged,
pubmed-meshheading:15607204-Case-Control Studies,
pubmed-meshheading:15607204-Chi-Square Distribution,
pubmed-meshheading:15607204-Female,
pubmed-meshheading:15607204-Genotype,
pubmed-meshheading:15607204-Humans,
pubmed-meshheading:15607204-Intercellular Adhesion Molecule-1,
pubmed-meshheading:15607204-Interleukin-8,
pubmed-meshheading:15607204-Male,
pubmed-meshheading:15607204-Middle Aged,
pubmed-meshheading:15607204-Multiple System Atrophy,
pubmed-meshheading:15607204-Odds Ratio,
pubmed-meshheading:15607204-Polymorphism, Genetic,
pubmed-meshheading:15607204-Risk,
pubmed-meshheading:15607204-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Interleukin-8, intercellular adhesion molecule-1 and tumour necrosis factor-alpha gene polymorphisms and the risk for multiple system atrophy.
|
|
pubmed:affiliation |
Neurology Service, University Hospital Marqués de Valdecilla, University of Cantabria, 39008 Santander, Spain.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
