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rdf:type |
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lifeskim:mentions |
umls-concept:C0011399,
umls-concept:C0017262,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0039038,
umls-concept:C0185117,
umls-concept:C0205092,
umls-concept:C0221198,
umls-concept:C0600251,
umls-concept:C0729269,
umls-concept:C1456820,
umls-concept:C2911684
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pubmed:issue |
6
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|
pubmed:dateCreated |
2004-10-6
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|
pubmed:abstractText |
Apical periodontitis is an inflammatory disease characterized by bone resorption, and sympathetic nerves are known to modulate bone resorption and bone remodeling. Higher numbers of osteoclasts and larger periapical lesions have been observed after sympathectomy in rats, but the mechanisms underlying the inhibitory effect of sympathetic nerves on osteoclasts are unknown. This study aimed to test the hypothesis that sympathetic nerves inhibit the production of the bone-resorbing pro-inflammatory cytokines IL-1 alpha and TNF-alpha in rat periapical lesions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:issn |
1021-7401
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
376-84
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15467353-Animals,
pubmed-meshheading:15467353-Bone Resorption,
pubmed-meshheading:15467353-Cytokines,
pubmed-meshheading:15467353-Denervation,
pubmed-meshheading:15467353-Dental Pulp,
pubmed-meshheading:15467353-Disease Models, Animal,
pubmed-meshheading:15467353-Down-Regulation,
pubmed-meshheading:15467353-Immunohistochemistry,
pubmed-meshheading:15467353-Interleukin-1,
pubmed-meshheading:15467353-Male,
pubmed-meshheading:15467353-Neural Inhibition,
pubmed-meshheading:15467353-Neuroimmunomodulation,
pubmed-meshheading:15467353-Neuropeptides,
pubmed-meshheading:15467353-Osteoclasts,
pubmed-meshheading:15467353-Periapical Periodontitis,
pubmed-meshheading:15467353-Rats,
pubmed-meshheading:15467353-Rats, Sprague-Dawley,
pubmed-meshheading:15467353-Sympathetic Fibers, Postganglionic,
pubmed-meshheading:15467353-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
IL-1 alpha and TNF-alpha expression in rat periapical lesions and dental pulp after unilateral sympathectomy.
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pubmed:affiliation |
Department of Physiology, Faculty of Medicine, University of Bergen, Bergen, Norway. Nancy.Bletsa@fys.uib.no
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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