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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-4-27
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pubmed:abstractText |
Modification of the vanillyl substituent on a potent, semisynthetic lymphocyte function-associated antigen (LFA)-1/intercellular adhesion molecule (ICAM)-1 binding inhibitor of the statin family resulted in metabolically more stable analogues that displayed submicromolar inhibitory activity in vitro and considerable anti-inflammatory activity in vivo. The benzodioxole derivative 2b emerged with the best overall profile.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2483-7
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pubmed:meshHeading |
pubmed-meshheading:15109637-Animals,
pubmed-meshheading:15109637-Anti-Inflammatory Agents,
pubmed-meshheading:15109637-Dose-Response Relationship, Drug,
pubmed-meshheading:15109637-Drug Stability,
pubmed-meshheading:15109637-Humans,
pubmed-meshheading:15109637-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:15109637-Inflammation,
pubmed-meshheading:15109637-Inhibitory Concentration 50,
pubmed-meshheading:15109637-Intercellular Adhesion Molecule-1,
pubmed-meshheading:15109637-Lovastatin,
pubmed-meshheading:15109637-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:15109637-Microsomes, Liver,
pubmed-meshheading:15109637-Protein Binding,
pubmed-meshheading:15109637-Rats,
pubmed-meshheading:15109637-Structure-Activity Relationship
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pubmed:year |
2004
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pubmed:articleTitle |
Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: stabilization of the metabolically labile vanillyl side chain.
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pubmed:affiliation |
Novartis Institutes for Biomedical Research, A-1235 Vienna, Austria. thomas.ullrich@pharma.novartis.com
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pubmed:publicationType |
Journal Article
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