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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2004-4-6
pubmed:abstractText
Matrix metalloproteinase 13 (MMP-13), urokinase type plasminogen activator (uPA), and plasminogen activator inhibitor type-1 (PAI-1) have been reported to be involved in aseptic loosening of artificial hip joints. This study for the first time presents the protein levels of all of these factors in synovial-like interfaces between bone and prosthesis and in pseudocapsular tissues surrounding the artificial joint in patients with aseptic loosening (n=17) measured by ELISA. No differences were observed in the antigen expression of MMP-13, uPA, and PAI-1, comparing interface and pseudocapsular tissue. Also, no significant correlation between the protein expression of these factors and years from arthroplasty to revision or to type of fixation (cemented vs. cementless) was observed. As control, MMP-13, uPA, and PAI-1 antigen levels were also determined in the synovium of patients with osteoarthritis (n=10). Yet, the antigen levels of MMP-13, uPA, and PAI-1 in tissue specimens from patients with aseptic loosening of artificial hip joints were significantly higher compared to their expression in synovial capsular tissues obtained from patients with osteoarthritis. In conclusion, this study shows that elevated protein levels of uPA, PAI-1, and MMP-13 in periprosthetic pseudocapsular and interface tissues from patients after total hip replacement due to aseptic loosening seem not to be associated with the patient outcome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1107-3756
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
711-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:15067375-Adult, pubmed-meshheading:15067375-Aged, pubmed-meshheading:15067375-Aged, 80 and over, pubmed-meshheading:15067375-Arthroplasty, Replacement, Hip, pubmed-meshheading:15067375-Collagenases, pubmed-meshheading:15067375-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:15067375-Female, pubmed-meshheading:15067375-Gene Expression Regulation, pubmed-meshheading:15067375-Hip Prosthesis, pubmed-meshheading:15067375-Humans, pubmed-meshheading:15067375-Joint Capsule, pubmed-meshheading:15067375-Male, pubmed-meshheading:15067375-Matrix Metalloproteinase 13, pubmed-meshheading:15067375-Middle Aged, pubmed-meshheading:15067375-Osteoarthritis, pubmed-meshheading:15067375-Plasminogen Activator Inhibitor 1, pubmed-meshheading:15067375-Prosthesis Failure, pubmed-meshheading:15067375-Reoperation, pubmed-meshheading:15067375-Treatment Outcome, pubmed-meshheading:15067375-Urokinase-Type Plasminogen Activator
pubmed:year
2004
pubmed:articleTitle
Protein expression of MMP-13, uPA, and PAI-1 in pseudocapsular and interface tissue around implants of loose artificial hip joints and in osteoarthritis.
pubmed:affiliation
Department of Orthopaedic Surgery, Technical University of Munich, D-81675 München, Germany. p.diehl@lrz.tum.de
pubmed:publicationType
Journal Article