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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
12
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pubmed:dateCreated |
2003-12-22
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pubmed:abstractText |
The rate of success in clinical transplantation of islets of Langerhans has dramatically improved with perspectives of wide-scale applicability for patients with type 1 diabetes. One drawback is the need for lifelong immunosuppression, which is associated with significant side effects. Immunomodulatory strategies devoid of side effects and with tolerogenic potential, such as co-stimulatory blockade, would be a great improvement if successful. In this study, the authors have explored the effect of simultaneous blockade of CD40/CD154 and intercellular adhesion molecule (ICAM)/lymphocyte function-associated antigen (LFA)-1 interactions.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0041-1337
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
76
|
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1669-74
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14688513-Animals,
pubmed-meshheading:14688513-Antibodies, Monoclonal,
pubmed-meshheading:14688513-Blood Glucose,
pubmed-meshheading:14688513-CD40 Ligand,
pubmed-meshheading:14688513-Diabetes Mellitus, Type 1,
pubmed-meshheading:14688513-Disease Models, Animal,
pubmed-meshheading:14688513-Graft Survival,
pubmed-meshheading:14688513-Immunosuppressive Agents,
pubmed-meshheading:14688513-Islets of Langerhans Transplantation,
pubmed-meshheading:14688513-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:14688513-Mice,
pubmed-meshheading:14688513-Mice, Inbred C57BL,
pubmed-meshheading:14688513-Mice, Inbred NOD,
pubmed-meshheading:14688513-Transplantation, Homologous
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pubmed:year |
2003
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|
pubmed:articleTitle |
The effect of simultaneous CD154 and LFA-1 blockade on the survival of allogeneic islet grafts in nonobese diabetic mice.
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pubmed:affiliation |
Cell Transplant Center, Diabetes Research Institute, University of Miami School of Medicine, 1450 NW 10th Avenue, Miami, FL 33136, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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