CD40 Ligand

Source:http://linkedlifedata.com/resource/umls/id/C0167627

NCI: CD40 ligand (261 aa, 29 kD) is a cellular division process protein that is encoded by the human CD40LG gene and has roles in inflammatory response, B-cell proliferation and anti-apoptosis.,NCI: A substance that is being studied in the treatment of cancer. It binds to certain immune cells and may suppress cancer growth.,MSH: A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.,PDQ: A recombinant therapeutic agent which is chemically identical to or similar to CD40-ligand. CD40-ligand, also known as CD40L/TRAP and CD154, is a type II membrane protein which binds to CD40, a cell surface receptor that belongs to the tumor necrosis factor receptor family; CD40 is expressed on B lymphocytes, monocytes, dendritic cells (DC), hematopoietic progenitors, endothelial cells and epithelial cells. Recombinant CD4

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