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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0032854,
umls-concept:C0054943,
umls-concept:C0079611,
umls-concept:C0220901,
umls-concept:C0280141,
umls-concept:C1413236,
umls-concept:C1521991,
umls-concept:C1561558,
umls-concept:C1881379,
umls-concept:C2348519
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pubmed:issue |
2
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pubmed:dateCreated |
1992-2-4
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pubmed:abstractText |
The authors studied six adult patients with acute leukemia with these unusual characteristics: unclassifiable morphology and undifferentiated cytochemistry by French-American-British (FAB) criteria; concurrent expression of CD13 (and CD33) myeloid and early T-cell CD7 immune markers; no evidence of T-cell lineage commitment as determined by T-cell receptor beta (beta), gamma (gamma), and delta (delta) chain gene rearrangement study and cytoplasmic CD3 epsilon expression; and no evidence of myeloid cell lineage commitment, as shown by absent myeloid-specific c-fms proto-oncogene expression and negative myeloperoxidase ultrastructural staining (one case). Clinically, these diagnostic features matched with a poor prognosis, being associated with refractoriness to treatment, relapse and progression of disease, antecedent hematologic abnormality, and other malignancy. These cases may represent a distinct stem cell leukemia syndrome deserving immediate recognition and a nonconventional chemotherapeutic approach.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD13,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD7,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
396-404
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1370211-Acute Disease,
pubmed-meshheading:1370211-Adult,
pubmed-meshheading:1370211-Antigens, CD,
pubmed-meshheading:1370211-Antigens, CD13,
pubmed-meshheading:1370211-Antigens, CD7,
pubmed-meshheading:1370211-Antigens, Differentiation,
pubmed-meshheading:1370211-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:1370211-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1370211-DNA, Neoplasm,
pubmed-meshheading:1370211-Female,
pubmed-meshheading:1370211-Fluorescent Antibody Technique,
pubmed-meshheading:1370211-Humans,
pubmed-meshheading:1370211-Immunophenotyping,
pubmed-meshheading:1370211-Leukemia,
pubmed-meshheading:1370211-Male,
pubmed-meshheading:1370211-Middle Aged,
pubmed-meshheading:1370211-Nucleotide Mapping,
pubmed-meshheading:1370211-Prognosis,
pubmed-meshheading:1370211-RNA, Neoplasm
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pubmed:year |
1992
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pubmed:articleTitle |
Acute undifferentiated leukemia with CD7+ and CD13+ immunophenotype. Lack of molecular lineage commitment and association with poor prognostic features.
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pubmed:affiliation |
Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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