|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001962,
umls-concept:C0017262,
umls-concept:C0040688,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0227525,
umls-concept:C1522538,
umls-concept:C1527195,
umls-concept:C1948023,
umls-concept:C2246343,
umls-concept:C2340138,
umls-concept:C2911684
|
|
pubmed:issue |
8 Suppl
|
|
pubmed:dateCreated |
2003-9-8
|
|
pubmed:abstractText |
Liver fibrosis often develops in alcoholic liver diseases without accompanying inflammation; however, the underlying mechanism is unclear. Using ethanol-exposed human HepG2 hepatoblastoma cells as a model for alcoholic liver diseases, we previously found that ethanol exposure causes HepG2 cells to secrete an approximately 6,000 Da nonheparin-binding polypeptide that stimulates collagen synthesis in human IMR-90 fibroblasts. The aim of the current study was to characterize and identify this factor.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0145-6008
|
|
pubmed:author |
pubmed-author:InuiNoriakiN,
pubmed-author:KatoJunjiJ,
pubmed-author:KobuneMasayoshiM,
pubmed-author:KohgoYutakaY,
pubmed-author:KuroiwaGanjiG,
pubmed-author:MiyakeSachieS,
pubmed-author:NakanoYoichiroY,
pubmed-author:NiitsuYoshiroY,
pubmed-author:SatoYasuhiroY,
pubmed-author:TakadaKohichK,
pubmed-author:TakimotoRishuR
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
58S-63S
|
|
pubmed:dateRevised |
2004-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:12960509-Blotting, Western,
pubmed-meshheading:12960509-Collagen,
pubmed-meshheading:12960509-Collagen Type I,
pubmed-meshheading:12960509-Culture Media, Conditioned,
pubmed-meshheading:12960509-Ethanol,
pubmed-meshheading:12960509-Gene Expression,
pubmed-meshheading:12960509-Hepatoblastoma,
pubmed-meshheading:12960509-Hepatocytes,
pubmed-meshheading:12960509-Humans,
pubmed-meshheading:12960509-Liver Cirrhosis, Alcoholic,
pubmed-meshheading:12960509-Liver Neoplasms,
pubmed-meshheading:12960509-RNA, Messenger,
pubmed-meshheading:12960509-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12960509-Transforming Growth Factor alpha,
pubmed-meshheading:12960509-Tumor Cells, Cultured,
pubmed-meshheading:12960509-Up-Regulation
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Ethanol induces transforming growth factor-alpha expression in hepatocytes, leading to stimulation of collagen synthesis by hepatic stellate cells.
|
|
pubmed:affiliation |
Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan. jkato@sapmed.ac.jp
|
|
pubmed:publicationType |
Journal Article
|
