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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2003-7-9
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pubmed:databankReference |
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pubmed:abstractText |
The mechanism of implantation in carnivores is poorly understood. However, a previously unidentified 60-kDa protein has been shown to be necessary for embryo implantation in ferrets. Here we identify this protein as glucose-6-phosphate isomerase (GPI). GPI is expressed by the corpus luteum on days 6-9 of pregnancy, the time at which implantation-promoting activity has been found in corpora lutea. Passive immunization against GPI reduced the number of implantation sites in pregnant ferrets in a dose-dependent manner. GPI is a multifunctional protein. Although first identified for its role in glycolysis, GPI has since been implicated in neural growth, lymphocyte maturation, and metastasis. This study demonstrates a previously uncharacterized function of this protein that may represent the natural motility-stimulating activity that has been co-opted by tumor cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-10329345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-10407139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-10456327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-10721002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-10882512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-11004567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-11431735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-11437381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-11787164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-1423599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-2491811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-3401538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-4853673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-5026657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-6217324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-667254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-6838952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-7139007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-7429529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-7521840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-7954394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-8371102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-9635595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12826606-9695791
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8561-6
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pubmed:dateRevised |
2011-5-6
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pubmed:meshHeading |
pubmed-meshheading:12826606-Amino Acid Sequence,
pubmed-meshheading:12826606-Animals,
pubmed-meshheading:12826606-Base Sequence,
pubmed-meshheading:12826606-Cell Movement,
pubmed-meshheading:12826606-Chickens,
pubmed-meshheading:12826606-Corpus Luteum,
pubmed-meshheading:12826606-Embryo Implantation,
pubmed-meshheading:12826606-Embryo Transfer,
pubmed-meshheading:12826606-Female,
pubmed-meshheading:12826606-Ferrets,
pubmed-meshheading:12826606-Glucose-6-Phosphate Isomerase,
pubmed-meshheading:12826606-Immunization, Passive,
pubmed-meshheading:12826606-Male,
pubmed-meshheading:12826606-Molecular Sequence Data,
pubmed-meshheading:12826606-Ovariectomy,
pubmed-meshheading:12826606-Pregnancy,
pubmed-meshheading:12826606-Pseudopregnancy,
pubmed-meshheading:12826606-Rabbits,
pubmed-meshheading:12826606-Sequence Alignment,
pubmed-meshheading:12826606-Sequence Homology,
pubmed-meshheading:12826606-Species Specificity,
pubmed-meshheading:12826606-Time Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Glucose-6-phosphate isomerase is necessary for embryo implantation in the domestic ferret.
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pubmed:affiliation |
Department of Molecular and Integrative Physiology, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801, USA. lcschulz@bu.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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