Source:http://linkedlifedata.com/resource/umls/id/C0017759
MSH: An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.,NCI: Encoded by human GPI Gene (GPI Family), Glucose-6-Phosphate Isomerase, Neuroleukin, and Autocrine Motility Factor function in different capacities. In glycolysis and gluconeogenesis, homodimeric cytoplasmic GPI catalyzes reversible G6P and F6P isomerization. Produced by lectin-stimulated T-cells, secreted non-mitogenic NLK lymphokine acts early in antibody-secreting cell