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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-2-17
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pubmed:abstractText |
Animal oocytes undergo a highly conserved developmental arrest in prophase of meiosis I. Often this marks a period of rapid growth for the oocyte and is necessary to coordinate meiotic progression with the developmental events of oogenesis. In Drosophila, the oocyte develops within a 16-cell germline cyst. Throughout much of oogenesis, the oocyte remains in prophase of meiosis I. By contrast, its 15 mitotic sisters enter the endocycle and become polyploid in preparation for their role as nurse cells. How germline cysts establish and maintain these two independent cell cycles is unknown. We demonstrate a role for the p21(CIP)/p27(Kip1)/p57(Kip2)-like cyclin-dependent kinase inhibitor (cki) dacapo in the maintenance of the meiotic cycle in Drosophila oocytes. Our data indicate that it is through the differential regulation of the cki Dacapo that two modes of cell-cycle regulation are independently maintained within the common cytoplasm of ovarian cysts.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0950-1991
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1235-42
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:12588841-Animals,
pubmed-meshheading:12588841-Cell Cycle Proteins,
pubmed-meshheading:12588841-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:12588841-Drosophila,
pubmed-meshheading:12588841-Drosophila Proteins,
pubmed-meshheading:12588841-Female,
pubmed-meshheading:12588841-Fluorescent Dyes,
pubmed-meshheading:12588841-Indoles,
pubmed-meshheading:12588841-Meiosis,
pubmed-meshheading:12588841-Nuclear Proteins,
pubmed-meshheading:12588841-Oocytes,
pubmed-meshheading:12588841-Prophase,
pubmed-meshheading:12588841-Tumor Suppressor Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
The p27cip/kip ortholog dacapo maintains the Drosophila oocyte in prophase of meiosis I.
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pubmed:affiliation |
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article
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