Source:http://linkedlifedata.com/resource/pubmed/id/12477328
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2002-12-12
|
| pubmed:abstractText |
The embedding of bacteria in the vegetation of infective endocarditis impedes the penetration of phagocytic cells. IL-8 has a stimulating effect on the immune system, particularly with respect to chemotaxis and activation of granulocytes. Tumor necrosis factor alpha (TNF-alpha) is 1 of the major proinflammatory cytokines. IL-8 and TNF-alpha were visualized by means of immunohistochemistry in paraffin-embedded heart valve biopsies from 6 patients with infective endocarditis who required cardiac surgery during the active phase of the infection. In 5/6 patients there were signs of inflammation, and in these patients IL-8- and TNF-alpha-containing cells were visualized in the heart valve stromas or vegetations. The largest numbers of IL-8-containing cells, and the greatest amount of inflammation, were seen in patients with short preoperative treatment courses. No such relationships were seen with respect to TNF-alpha-containing cells. These observations may suggest that the occurrence of IL-8-containing cells in infected heart valves could be used as a marker of disease activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0036-5548
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
759-62
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12477328-Adult,
pubmed-meshheading:12477328-Aged,
pubmed-meshheading:12477328-Bacterial Infections,
pubmed-meshheading:12477328-Biological Markers,
pubmed-meshheading:12477328-Biopsy, Needle,
pubmed-meshheading:12477328-Endocarditis, Bacterial,
pubmed-meshheading:12477328-Female,
pubmed-meshheading:12477328-Gram-Negative Bacteria,
pubmed-meshheading:12477328-Gram-Positive Bacteria,
pubmed-meshheading:12477328-Heart Valve Diseases,
pubmed-meshheading:12477328-Heart Valves,
pubmed-meshheading:12477328-Humans,
pubmed-meshheading:12477328-Immunohistochemistry,
pubmed-meshheading:12477328-Interleukin-8,
pubmed-meshheading:12477328-Male,
pubmed-meshheading:12477328-Middle Aged,
pubmed-meshheading:12477328-Prospective Studies,
pubmed-meshheading:12477328-Sensitivity and Specificity,
pubmed-meshheading:12477328-Severity of Illness Index,
pubmed-meshheading:12477328-Tumor Necrosis Factor-alpha
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
IL-8 and tumor necrosis factor alpha in heart valves from patients with infective endocarditis.
|
| pubmed:affiliation |
Department of Infectious Diseases, University Hospital of Linköping, Sweden. Christer.Ekdahl@inf.liu.se
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|