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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2002-4-22
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pubmed:abstractText |
During asymmetric cell division in the Drosophila nervous system, Numb segregates into one of two daughter cells where it is required for the establishment of the correct cell fate. Numb is uniformly cortical in interphase, but in late prophase, the protein concentrates in the cortical area overlying one of two centrosomes in an actin/myosin-dependent manner. What triggers the asymmetric localization of Numb at the onset of mitosis is unclear.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eg2 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Juvenile Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/aurora kinase,
http://linkedlifedata.com/resource/pubmed/chemical/centrosomin protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/numb protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
640-7
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pubmed:dateRevised |
2011-7-11
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pubmed:meshHeading |
pubmed-meshheading:11967150-Actins,
pubmed-meshheading:11967150-Animals,
pubmed-meshheading:11967150-Cell Cycle Proteins,
pubmed-meshheading:11967150-Centrosome,
pubmed-meshheading:11967150-Drosophila,
pubmed-meshheading:11967150-Drosophila Proteins,
pubmed-meshheading:11967150-Homeodomain Proteins,
pubmed-meshheading:11967150-Juvenile Hormones,
pubmed-meshheading:11967150-Microscopy, Fluorescence,
pubmed-meshheading:11967150-Mitosis,
pubmed-meshheading:11967150-Mitotic Spindle Apparatus,
pubmed-meshheading:11967150-Nervous System,
pubmed-meshheading:11967150-Protein Kinases,
pubmed-meshheading:11967150-Protein Transport,
pubmed-meshheading:11967150-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11967150-Time Factors,
pubmed-meshheading:11967150-Xenopus Proteins
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pubmed:year |
2002
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pubmed:articleTitle |
Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.
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pubmed:affiliation |
Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr Gasse 7, A-1030, Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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