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rdf:type |
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lifeskim:mentions |
umls-concept:C0001857,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0031727,
umls-concept:C0033640,
umls-concept:C0080058,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0282625,
umls-concept:C0521119,
umls-concept:C0752312,
umls-concept:C0815000,
umls-concept:C0851285,
umls-concept:C1546857,
umls-concept:C1882534,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
2002-3-6
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pubmed:abstractText |
We examined the effect of insulin on the expression of the activity-regulated cytoskeleton-associated gene (ARC), an effector immediate early gene with a proposed role in memory formation. In human SH-SY5Y neuroblastoma cells, application of insulin leads to dramatic increase in ARC mRNA and protein levels. Inhibition experiments reveal, that p21(ras), mitogen-activated protein kinase/extracellular regulated kinase and tyrosine kinase (src) activity are required for the insulin-induced ARC expression in SH-SY5Y cells, whereas protein kinase C is not involved in the signal transduction pathway. Our data indicated for the first time a correlation of the insulin-controlled signal cascade and the induction of synaptic plasticity-associated immediate early genes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/HRAS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins p21(ras),
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/activity regulated...,
http://linkedlifedata.com/resource/pubmed/chemical/src-Family Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
321
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11880195-Central Nervous System,
pubmed-meshheading:11880195-Cytoskeletal Proteins,
pubmed-meshheading:11880195-Enzyme Inhibitors,
pubmed-meshheading:11880195-Gene Expression Regulation, Developmental,
pubmed-meshheading:11880195-Humans,
pubmed-meshheading:11880195-Insulin,
pubmed-meshheading:11880195-Memory,
pubmed-meshheading:11880195-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11880195-Nerve Tissue Proteins,
pubmed-meshheading:11880195-Neuroblastoma,
pubmed-meshheading:11880195-Neuronal Plasticity,
pubmed-meshheading:11880195-Neurons,
pubmed-meshheading:11880195-Protein Kinase C,
pubmed-meshheading:11880195-Proto-Oncogene Proteins p21(ras),
pubmed-meshheading:11880195-RNA, Messenger,
pubmed-meshheading:11880195-Signal Transduction,
pubmed-meshheading:11880195-Synapses,
pubmed-meshheading:11880195-Transcription, Genetic,
pubmed-meshheading:11880195-Tumor Cells, Cultured,
pubmed-meshheading:11880195-src-Family Kinases
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pubmed:year |
2002
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pubmed:articleTitle |
Insulin-induced expression of the activity-regulated cytoskeleton-associated gene (ARC) in human neuroblastoma cells requires p21(ras), mitogen-activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent.
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pubmed:affiliation |
Department for Experimental Tumor Biology, University Muenster, Badestrasse 9, 48149 Muenster, Germany. kremers@uni-muenster.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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