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11327603
Source:
http://linkedlifedata.com/resource/pubmed/id/11327603
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Statements in which the resource exists as a subject.
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Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0063695
,
umls-concept:C0079717
,
umls-concept:C0243076
,
umls-concept:C0268563
,
umls-concept:C1704675
,
umls-concept:C1880355
pubmed:issue
8
pubmed:dateCreated
2001-4-30
pubmed:abstractText
Diarylsulfide cyclopropylamides were synthesized and evaluated as LFA-1/ICAM-1 interaction antagonists. A substituent pattern was identified which maximized potency and minimized protein binding as exemplified by antagonist 30 (IC50 = 5 nM).
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Amides
,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclopropanes
,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1
,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0960-894X
pubmed:author
pubmed-author:LeitzaSS
,
pubmed-author:LinNN
,
pubmed-author:LindJ MJM
,
pubmed-author:OkasinskiGG
,
pubmed-author:PerSS
,
pubmed-author:ReillyE BEB
,
pubmed-author:SorensenBB
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
973-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed-meshheading:11327603-Administration, Oral
,
pubmed-meshheading:11327603-Amides
,
pubmed-meshheading:11327603-Animals
,
pubmed-meshheading:11327603-Area Under Curve
,
pubmed-meshheading:11327603-Biological Availability
,
pubmed-meshheading:11327603-Cell Communication
,
pubmed-meshheading:11327603-Cyclopropanes
,
pubmed-meshheading:11327603-Endothelium
,
pubmed-meshheading:11327603-Inhibitory Concentration 50
,
pubmed-meshheading:11327603-Intercellular Adhesion Molecule-1
,
pubmed-meshheading:11327603-Leukocytes
,
pubmed-meshheading:11327603-Lymphocyte Function-Associated Antigen-1
,
pubmed-meshheading:11327603-Protein Binding
,
pubmed-meshheading:11327603-Rats
,
pubmed-meshheading:11327603-Structure-Activity Relationship
pubmed:year
2001
pubmed:articleTitle
Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists.
pubmed:affiliation
Metabolic Disease Research, Abbott Laboratories, Abbott Park, IL 60064, USA. james.link@abbott.com
pubmed:publicationType
Journal Article