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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0109317,
umls-concept:C0185117,
umls-concept:C0752312,
umls-concept:C1150579,
umls-concept:C1280500,
umls-concept:C1333340,
umls-concept:C1366882,
umls-concept:C1370600,
umls-concept:C1456820,
umls-concept:C1521805,
umls-concept:C1705767,
umls-concept:C1705791,
umls-concept:C1720857,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2001-3-30
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pubmed:abstractText |
Tumor necrosis factor-alpha (TNF-alpha) activates extracellular-regulated kinases (ERKs) and p38 mitogen-activated protein kinase (p38MAPK), and inhibits the expression of uncoupling protein-1 (UCP-1) and adipocyte-specific genes in rat fetal brown adipocytes. MEK inhibition with PD98059 abolished the inhibitory effect of TNF-alpha on UCP-1, but not on adipogenic genes. In contrast, inhibition of p38MAPK with SB203580 potentiated the negative effect of TNF-alpha on UCP-1 and adipogenic genes. The inhibitory action of TNF-alpha was partially correlated with changes in C/EBPalpha and beta protein levels and in their DNA binding activity, suggesting a role for these transcription factors. However, other transcription factors might explain the different regulation of UCP-1 and adipogenic genes by ERKs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Protein-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Protein-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/MAP-kinase-activated kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/SB 203580,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
493
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6-11
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11277995-Adipocytes,
pubmed-meshheading:11277995-Adipose Tissue, Brown,
pubmed-meshheading:11277995-Animals,
pubmed-meshheading:11277995-Apoptosis,
pubmed-meshheading:11277995-Blotting, Northern,
pubmed-meshheading:11277995-Blotting, Western,
pubmed-meshheading:11277995-CCAAT-Enhancer-Binding Protein-alpha,
pubmed-meshheading:11277995-CCAAT-Enhancer-Binding Protein-beta,
pubmed-meshheading:11277995-Carrier Proteins,
pubmed-meshheading:11277995-Cell Differentiation,
pubmed-meshheading:11277995-Cell Nucleus,
pubmed-meshheading:11277995-Cells, Cultured,
pubmed-meshheading:11277995-Enzyme Inhibitors,
pubmed-meshheading:11277995-Flavonoids,
pubmed-meshheading:11277995-Imidazoles,
pubmed-meshheading:11277995-Insulin-Like Growth Factor I,
pubmed-meshheading:11277995-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:11277995-Ion Channels,
pubmed-meshheading:11277995-Membrane Proteins,
pubmed-meshheading:11277995-Mitochondrial Proteins,
pubmed-meshheading:11277995-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:11277995-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11277995-Protein Binding,
pubmed-meshheading:11277995-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11277995-Pyridines,
pubmed-meshheading:11277995-RNA,
pubmed-meshheading:11277995-Rats,
pubmed-meshheading:11277995-Transcription Factors,
pubmed-meshheading:11277995-Tumor Necrosis Factor-alpha,
pubmed-meshheading:11277995-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2001
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pubmed:articleTitle |
TNF-alpha inhibits UCP-1 expression in brown adipocytes via ERKs. Opposite effect of p38MAPK.
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pubmed:affiliation |
Departamento de Bioquímica y Biología Molecular II, Instituto de Bioquímica (Centro Mixto del Consejo Superior de Investigaciones Científicas (C.S.I.C.) y de la Universidad Complutense de Madrid (U.C.M.)), Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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