Linked Life Data

11102891

Source:http://linkedlifedata.com/resource/pubmed/id/11102891

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-12-13
pubmed:abstractText
Epidermal growth factor receptor (EGF-R) and its ligand, transforming growth factor-alpha (TGF-alpha), play an important role through the autocrine growth-regulation system in several human cancers, including breast cancer. However, the clinical significance of co-expression of EGF-R and TGF-alpha has not been elucidated. One hundred seventy-three female patients diagnosed as invasive ductal carcinoma who had undergone a mastectomy (159 patients) or breast-conserving surgery (14 patients) were followed up for 81 to 119 months (median 94 months) post-operatively. Immunoreactivity for EGF-R, TGF-alpha, p53 and c-erbB-2 with paraffin-embedded carcinoma tissue was investigated using labeled streptavidin-biotin methods. Positive rates of carcinoma cells were 27%, 33%, 32% and 26% for EGF-R, TGF-alpha, p53 and c-erbB-2, respectively. Expression of EGF-R only was observed in 16% (28/173), of TGF-alpha only in 22% (38/173), of both EGF-R and TGF-alpha in 11% (19/173) and of neither in 51% (88/173). By univariate analysis, significant differences in overall survival and disease-free survival were noted according to the co-expression of EGF-R and TGF-alpha (p< 0.0001, p<0.0001), co-expression of EGF-R and c-erbB-2 (p = 0.0029, p = 0.0028), nodal status (p = 0.0028, p = 0.0001), tumor size (p = 0.0001, p<0.0001) and c-erbB-2 expression (p = 0.0034, p = 0.018), respectively. The status of p53 expression (p = 0.01), estrogen receptor (p = 0.042) and progesterone receptor (p = 0.046) showed significant differences in overall survival. According to Cox's multivariate analysis, co-expression of EGF-R and TGF-alpha had the most significant effect on disease-free survival (p<0.0001) and overall survival (p<0.0001), followed by nodal status. Co-expression of EGF-R and TGF-alpha by immunohistochemical detection is an independent prognostic indicator, and it may be helpful for determining the group of breast-cancer patients with an aggressive phenotype.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0020-7136
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
484-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11102891-Adult, pubmed-meshheading:11102891-Aged, pubmed-meshheading:11102891-Aged, 80 and over, pubmed-meshheading:11102891-Breast Neoplasms, pubmed-meshheading:11102891-Carcinoma, Ductal, Breast, pubmed-meshheading:11102891-Disease-Free Survival, pubmed-meshheading:11102891-Female, pubmed-meshheading:11102891-Humans, pubmed-meshheading:11102891-Middle Aged, pubmed-meshheading:11102891-Multivariate Analysis, pubmed-meshheading:11102891-Predictive Value of Tests, pubmed-meshheading:11102891-Proportional Hazards Models, pubmed-meshheading:11102891-Receptor, Epidermal Growth Factor, pubmed-meshheading:11102891-Receptor, erbB-2, pubmed-meshheading:11102891-Survival Analysis, pubmed-meshheading:11102891-Transforming Growth Factor alpha, pubmed-meshheading:11102891-Tumor Suppressor Protein p53
pubmed:year
2000
pubmed:articleTitle
Co-expression of epidermal growth factor receptor and transforming growth factor-alpha predicts worse prognosis in breast-cancer patients.
pubmed:affiliation
Department of Pathology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't