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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-8-17
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pubmed:abstractText |
There is increasing evidence that the colony-stimulating factors (CSFs) may play a part in chronic inflammatory autoimmune diseases, such as rheumatoid arthritis (RA). We examined the involvement of macrophage CSF (M-CSF or CSF-1) and granulocyte CSF (G-CSF) in collagen-induced arthritis (CIA), a murine model of RA. Daily injections of M-CSF or G-CSF, 20-24 days postprimary immunization with type II collagen, exacerbated disease symptoms in suboptimally immunized DBA/1 mice. Support for the involvement of endogenous M-CSF in CIA was obtained by studies in which neutralizing monoclonal antibody reduced the severity of established CIA and also by studies showing the resistance of M-CSF-deficient op/op mice to CIA induction. These studies show that M-CSF and G-CSF can be proinflammatory in CIA and provide evidence that macrophage- and granulocyte-lineage cells can exacerbate CIA. Our results also show that M-CSF-dependent cells are essential for CIA development, suggesting M-CSF may be a suitable target for therapeutic intervention in RA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0741-5400
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
144-50
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10914502-Animals,
pubmed-meshheading:10914502-Antibodies, Monoclonal,
pubmed-meshheading:10914502-Arthritis, Rheumatoid,
pubmed-meshheading:10914502-Autoimmune Diseases,
pubmed-meshheading:10914502-Cell Lineage,
pubmed-meshheading:10914502-Chickens,
pubmed-meshheading:10914502-Collagen,
pubmed-meshheading:10914502-Disease Models, Animal,
pubmed-meshheading:10914502-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:10914502-Granulocytes,
pubmed-meshheading:10914502-Immunity, Innate,
pubmed-meshheading:10914502-Immunization,
pubmed-meshheading:10914502-Interleukin-1,
pubmed-meshheading:10914502-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:10914502-Macrophages,
pubmed-meshheading:10914502-Male,
pubmed-meshheading:10914502-Mice,
pubmed-meshheading:10914502-Mice, Inbred C3H,
pubmed-meshheading:10914502-Mice, Inbred C57BL,
pubmed-meshheading:10914502-Mice, Inbred DBA,
pubmed-meshheading:10914502-Mice, Mutant Strains,
pubmed-meshheading:10914502-Osteopetrosis,
pubmed-meshheading:10914502-Rats,
pubmed-meshheading:10914502-Recombinant Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF.
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pubmed:affiliation |
Inflammation Research Centre, The University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia. campbell@wehi.edu.au
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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