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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-5-31
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pubmed:abstractText |
Adxanthromycins A and B are new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule isolated from the fermentation broth of Streptomyces sp. NA-148. The molecular formula of adxanthromycins A and B were determined as C42H40O17 and C48H50O22, respectively by FAB-MS and NMR spectral analyses, and the structures of both compounds were elucidated to be a dimeric anthrone peroxide skeleton containing alpha-D-galactose by various NMR spectral analyses and chemical degradation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-70
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:10805577-Anti-Bacterial Agents,
pubmed-meshheading:10805577-Drug Evaluation, Preclinical,
pubmed-meshheading:10805577-Fermentation,
pubmed-meshheading:10805577-Intercellular Adhesion Molecule-1,
pubmed-meshheading:10805577-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:10805577-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10805577-Molecular Structure,
pubmed-meshheading:10805577-Peroxides,
pubmed-meshheading:10805577-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:10805577-Streptomyces,
pubmed-meshheading:10805577-Xanthenes
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pubmed:year |
2000
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pubmed:articleTitle |
Adxanthromycins A and B, new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule from Streptomyces sp. NA-148. II. Physico-chemical properties and structure elucidation.
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pubmed:affiliation |
Department of Biosciences, Teikyo University, Utsunomiya, Japan.
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pubmed:publicationType |
Journal Article
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